Reference : Cell-based description of ventricular contraction in a model of the human cardiovascu...
Scientific congresses and symposiums : Paper published in a journal
Physical, chemical, mathematical & earth Sciences : Multidisciplinary, general & others
http://hdl.handle.net/2268/185805
Cell-based description of ventricular contraction in a model of the human cardiovascular system
English
Kosta, Sarah mailto [Université de Liège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles >]
Negroni, Jorge [Favaloro University > Department of Comparative Cellular and Molecular Biology > > >]
Lascano, Elena [Favaloro University > Department of Comparative Cellular and Molecular Biology > > >]
Dauby, Pierre mailto [Université de Liège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles >]
Sep-2015
IFAC-PapersOnLine
147-152
Yes
No
International
9th IFAC Symposium on Biological and Medical Systems (BMS 2015)
31 août 2015 au 2 septembre 2015
The International Federation of Automatic Control
Berlin
Allemagne
[en] Mathematical models ; Physiological models ; Multiscale models ; Cardiovascular system
[en] A multiscale model of the cardiovascular system (CVS) is presented. Hemodynamics is described by a lumped parameter model, while heart contraction is described at the cellular scale. An electrophysiological model and a mechanical model were coupled and adjusted so that the pressure and volume of both ventricles are linked to the force and length of a half-sarcomere.
Particular attention was paid to the extremal values of the sarcomere length, which must
keep physiological values. This model is able to reproduce healthy behavior, preload variations
experiments, and ventricular failure.
http://hdl.handle.net/2268/185805
10.1016/j.ifacol.2015.10.130

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