Cell-based description of ventricular contraction in a model of the human cardiovascular system

[en] A multiscale model of the cardiovascular system (CVS) is presented. Hemodynamics is described by a lumped parameter model, while heart contraction is described at the cellular scale. An electrophysiological model and a mechanical model were coupled and adjusted so that the pressure and volume of both ventricles are linked to the force and length of a half-sarcomere. Particular attention was paid to the extremal values of the sarcomere length, which must keep physiological values. This model is able to reproduce healthy behavior, preload variations experiments, and ventricular failure.

Disciplines :

Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others

Author, co-author :

Kosta, Sarah ; Université de Liège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles

Negroni, Jorge; Favaloro University > Department of Comparative Cellular and Molecular Biology

Lascano, Elena; Favaloro University > Department of Comparative Cellular and Molecular Biology

Dauby, Pierre ; Université de Liège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles

Language :

English

Title :

Cell-based description of ventricular contraction in a model of the human cardiovascular system

Publication date :

September 2015

Event name :

9th IFAC Symposium on Biological and Medical Systems (BMS 2015)

Event organizer :

The International Federation of Automatic Control

Event place :

Berlin, Germany

Event date :

31 août 2015 au 2 septembre 2015

Audience :

International

Journal title :

IFAC-PapersOnLine

ISSN :

2405-8971

eISSN :

2405-8963

Publisher :

Elsevier, Kidlington, United Kingdom

Pages :

147-152

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 10 September 2015

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Bibliography

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