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Cell-based description of ventricular contraction in a model of the human cardiovascular system
Kosta, Sarah; Negroni, Jorge; Lascano, Elena et al.
2015In IFAC-PapersOnLine, p. 147-152
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Keywords :
Mathematical models; Physiological models; Multiscale models; Cardiovascular system
Abstract :
[en] A multiscale model of the cardiovascular system (CVS) is presented. Hemodynamics is described by a lumped parameter model, while heart contraction is described at the cellular scale. An electrophysiological model and a mechanical model were coupled and adjusted so that the pressure and volume of both ventricles are linked to the force and length of a half-sarcomere. Particular attention was paid to the extremal values of the sarcomere length, which must keep physiological values. This model is able to reproduce healthy behavior, preload variations experiments, and ventricular failure.
Disciplines :
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others
Author, co-author :
Kosta, Sarah ;  Université de Liège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Negroni, Jorge;  Favaloro University > Department of Comparative Cellular and Molecular Biology
Lascano, Elena;  Favaloro University > Department of Comparative Cellular and Molecular Biology
Dauby, Pierre  ;  Université de Liège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Language :
English
Title :
Cell-based description of ventricular contraction in a model of the human cardiovascular system
Publication date :
September 2015
Event name :
9th IFAC Symposium on Biological and Medical Systems (BMS 2015)
Event organizer :
The International Federation of Automatic Control
Event place :
Berlin, Germany
Event date :
31 août 2015 au 2 septembre 2015
Audience :
International
Journal title :
IFAC-PapersOnLine
ISSN :
2405-8971
eISSN :
2405-8963
Publisher :
Elsevier, Kidlington, United Kingdom
Pages :
147-152
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 10 September 2015

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