Article (Scientific journals)
The dual action of estrogen hypothesis
Cornil, Charlotte; Ball, Gregory F.; Balthazart, Jacques
2015In Trends in Neurosciences, 38 (7), p. 408-16
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Keywords :
appetitive behavior; consummatory behavior; estrogen; membrane-initiated action; motivation; nuclear action; performance
Abstract :
[en] Estradiol (E2) can act in the brain in a relatively fast manner (i.e., seconds to minutes) usually through signaling initiated at the cell membrane. Brain-derived E2 has thus been considered as another type of neurotransmitter. Recent work found that behaviors indicative of male sexual motivation are activated by estrogenic metabolites of testosterone (T) in a fast manner, while sexual performance (copulatory behavior per se) is regulated by brain E2 in a slower manner via nucleus-initiated actions. This functional division between these two types of action appears to generalize to other behavioral systems regulated by E2. We propose the dual action of estrogen hypothesis to explain this functional distinction between these two different modes of action.
Research center :
Giga-Neurosciences - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Cornil, Charlotte  ;  Université de Liège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Ball, Gregory F.
Balthazart, Jacques  ;  Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Language :
English
Title :
The dual action of estrogen hypothesis
Publication date :
2015
Journal title :
Trends in Neurosciences
ISSN :
0166-2236
Publisher :
Elsevier Science, Barking, United Kingdom
Volume :
38
Issue :
7
Pages :
408-16
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
NIH - National Institutes of Health [US-MD]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 04 September 2015

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