[en] Paraneoplastic hypercalcemia and hypercalcemia associated with neoplastic syndromes are particularly resistant to conventional hypocalcemic treatments. We present and discuss two case reports in which Cinacalcet was used to control hypercalcemia. Paraneoplastic hypercalcemia is present in the first case report, in association with a metastasic neuroendocrine pancreas. In the second case report ,cinacalcet is used to control hypecalcemia in a patient with multiple endocrine neoplasia and hyperparathyroidism not controlled by neck surgery.
Cinacalcet is an oral agonist of the Calcium Sensing Receptor. The hypocalcemic effects of Cinacalcet have not been documented so far in hypercalcemia-paraneo plastic linked to cancer of the pancreas (Valdés-Socin & al. Rev Med Switzerland 2009). On the other hand, its use seems promising in the MEN1-associated hyperparathyroidism. (Giusti & al. Endocrine 2015).
