Cell Type-Specific Role for Reactive Oxygen Species in Nuclear Factor-Kappab Activation by Interleukin-1

Bonizzi, G.; Piette, Jacques; Merville, Marie-Paule; Bours, Vincent

doi:10.1016/S0006-2952(99)00290-7

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Cell Type-Specific Role for Reactive Oxygen Species in Nuclear Factor-Kappab Activation by Interleukin-1

Bonizzi, G.; Piette, Jacques; Merville, Marie-Paule et al.

2000 • In Biochemical Pharmacology, 59 (1), p. 7-11

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https://hdl.handle.net/2268/18489

DOI
10.1016/S0006-2952(99)00290-7

PubMed
10605929

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Abstract :

[en] The role of reactive oxygen intermediates (ROIs) in nuclear factor-kappaB (NF-kappaB) activation remains a matter of controversy. We have studied whether ROIs played any role in NF-kappaB induction by interleukin-1beta (IL-1beta) in different cell types. Our studies indicated three different pathways. IL-1beta stimulation of lymphoid cells generates ROIs, which are required for IkappaB-alpha degradation and NF-kappaB activation. The source of these ROIs is the 5-lipoxygenase (5-LOX) enzyme. In monocytic cells, ROIs are also produced in response to IL-1beta and necessary for NF-kappaB induction, but their source appears to be the NADPH oxidase complex. Finally, epithelial cells do not generate ROIs after IL-1beta stimulation, but do rapidly activate NF-kappaB. Interestingly, transfection of epithelial cells with the 5-LOX and 5-LOX activating protein expression vectors restored ROI production and ROI-dependent NF-kappaB activation in response to IL-1beta. Our data thus indicate that ROIs are cell type-specific second messengers for NF-kappaB induction by IL-1beta.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Bonizzi, G.

Piette, Jacques ; Université de Liège - ULiège > Département des sciences de la vie > Virologie - Immunologie

Merville, Marie-Paule ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Bours, Vincent ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique générale et humaine

Language :

English

Title :

Cell Type-Specific Role for Reactive Oxygen Species in Nuclear Factor-Kappab Activation by Interleukin-1

Publication date :

01 January 2000

Journal title :

Biochemical Pharmacology

ISSN :

0006-2952

eISSN :

1873-2968

Publisher :

Elsevier, Netherlands

Volume :

Issue :

Pages :

7-11

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 11 August 2009

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