[en] A mesenchymal hamartoma in the dorsomedial eyelid of a Staffordshire bull terrier and the incidence and histological features of twenty-two canine mesenchymal periocular hamartoma cases are reported. The archives of the “Comparative Ocular Pathology Laboratory” of Wisconsin (USA) were searched for canine mesenchymal periocular hamartoma. Signalment, clinical appearance, location and histological findings are summarized for twenty-two dogs, containing fourteen different breeds, between four and fourteen years old. Fifteen hamartomas were located at the lateral canthus. Histologically, they consisted of fully differentiated fibrous tissue interspersed with adipose tissue, with bundles of skeletal/smooth muscle in ten cases, and peripheral nerve tissue in two cases. No mitotic figures were noted. Mesenchymal hamartomas may present as a subcutaneous, subconjunctival or orbital mass. Although they have a predisposition to occur at the lateral canthus, they may be located elsewhere on the eyelids or in the orbit.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Storms, Goedele ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Dép. clinique des animaux de compagnie et des équidés (DCA)
Janssens, Gerlinde
Grauwels, Magda ; Université de Liège > Clinique des grands animaux (chirurgie)
Dubielzig, Richard
Language :
English
Title :
Unusual presentation of a mesenchymal eyelid hamartoma and an update of the incidence of periocular hamartomas in dogs
Abel A., Brockbank D.T., Farber, M., Meyer D.R. (2004). Bony hamartoma of the inferior orbital rim in a patient with tuberous sclerosis. Archives of Ophthalmology 122, 780-782.
Beccaglia M., Battocchio M., Sironi G., Luvoni G.C. (2008). Unusual vaginal angiomatous neoformation in a 3-year old pug. Reproduction in Domestic Animals 43, 144-146.
Bemelmans I., Küry S., Albaric O., Hordeaux J., Bertrand L., Nguyen F., Abadie J. (2011). Colorectal hamartomatous polyposis and ganglioneuromatosis in a dog. Veterinary Pathology 48, 1012-1015.
Booler H. (2008). Congenital intrahepatic vascular anomaly in a clinically normal laboratory beagle. Toxicologic Pathology 36, 981-984.
Bradfield Y.S., Kulkarni A., Potter H.D., Warner T., Albert D.M. (2007). Eyelid fibrous hamartoma with conjunctival angioma in an infant. Archives of Ophthalmology 125, 843-845.
Brown D.L., Anderson M., Cullen J.M. (2007). Mesenchymal hamartoma of the liver in a late-term equine fetus. Veterinary Pathology 44, 100-102.
Brown P.J., Adam S.M., Wotton P.R., Gibbs C., Swan R.H. (1994). Hamartomatous polyps in the intestine of two dogs. Journal of Comparative Pathology 110, 97-102.
Callan M.B., Preziosi D., Mauldin E. (2005). Multiple papillomavirus-associated epidermal hamartomas and squamous cell carcinomas in situ in a dog following chronic treatment with prednisone and cyclosporine. Veterinary Dermatology 16, 338-345.
Chanoit G., Mathews K.G., Keene B.W., Small M.T., Linder, K. (2012). Surgical treatment of a pulmonary artery vascular hamartoma in a dog. Journal of the American Veterinary Medical Association 240, 858-862.
Cook R.W. (1977). Hypothalamic hamartoma in a dog. Veterinary Pathology 14, 138-145.
Corzo-Menéndez N., White R.N., Whitelock R.G., Blunden A.S. (2001). Vascular hamartoma within the flexor muscles of the left carpus in a dog. Journal of Small Animal Practice 42, 399-402.
Cushing T.L., Lopate C., Schlafer D.H. (2011). Benign placental mass with fetal growth retardation in a bull mastiff. Journal of Comparative Pathology 145, 352-354.
Fontcuberta I.C., Salomao D.R., Quiram P.A., Pulido J.S. (2011). Choroidal melanoma and lid fibrofoliculomas in Birt-Hogg-Dubé syndrome. Ophthalmic Genetics 32, 143-146.
Fry M.M., Decock H.E., Greeley M.A., Vernau W. (2003). Abdominal fluid from a dog. Veterinary Clinical Pathology 32, 77-80.
Ginn P.E., Mansell J.E.K.L., Rakich P.M. (2007). Skin and appendages. In: Grant Maxie M. (editor). Jubb, Kennedy and Palmer's Pathology of Domestic Animals. Fifth edition, vol. 1, Elsevier Saunders, Philadelphia, p. 556-780.
Greci V., Mortellaro C.M., Olivero D., Cocci A., Hawkins E.C. (2011). Inflammatory polyps of the nasal turbinates of cats: an argument for designation as feline mesenchymal nasal hamartoma. Journal of Feline Medicine and Surgery 13, 213-219.
Gualtieri M., Cocci A., Monti S., Olivero D. (2009). Surgical removal of a localised vascular hepatic hamartoma in a dog. Australian Veterinary Journal 87, 360-362.
Gündüz K., Kurt R.A., Kaygusuz G., Kankaya D. (2009). Primary chondromesenchymal hamartoma of the orbit. Ophthalmic Plastic and Reconstructive Surgery 25, 324-327.
Harris M.A., Dutton J.J., Proia A.D. (2008). Striated muscle hamartoma of the eyelid in an adult woman. Ophthalmic Plastic and Reconstructive Surgery 24, 492-494.
Ide T., Uchida K., Morozumi M., Nakayama H. (2009). Hamartoma in the medulla oblongata with marked mineral deposits in a dog. Journal of Veterinary Medical Science 71, 1097-1100.
Jakobiec F.A., Zakka F.R., Kim N. (2012). Basaloid follicular hamartoma of the eyelid. Ophthalmic Plastic and Reconstructive Surgery 28, 127-130.
Johnson M.D., Jacobs A.H. (1989). Congenital smooth muscle hamartoma. A report of six cases and review of the literature. Archives of Dermatology 125, 820-822.
Kafarnik C., Calvarese S., Dubielzig R.R. (2010). Canine mesenchymal hamartoma of the eyelid. Veterinary Ophthalmology 13, 94-98.
Kodsi S.R., Bloom K.E., Egbert J.E., Holland E.J., Cameron J.D. (1994). Ocular and systemic manifestations of encephalocraniocutaneous lipomatosis. American Journal of Ophthalmology 118, 77-82.
Koti K., Bhimireddy V., Dandamudi S., Gunnamreddy R. (2013). Encephalocraniocutaneous lipomatosis (Haberland syndrome): a case report and review of literature. Indian Journal of Dermatology 58, 232-234.
Kumar V., Abbas A.K., Aster J.C. (2013). Genetic and pediatric diseases. In: Kumar V., Abbas A.K., Aster J.C. (editors). Robbins Basic Pathology. Ninth editon, Elsevier Saunders, Philadelphia, p. 257.
Leroith T., Binder E.M., Graham A.H., Duncan R.B. (2009). Respiratory epithelial adenomatoid hamartoma in a dog. Journal of Veterinary Diagnostic Investigation 21, 918-920.
Lessner A., Margo C.E. (1991). Eyelid tumors in the proteus syndrome. American Journal of Ophthalmology 111, 521-522.
Li Y., Yang Q.X., Tian X.T., Li B., Li Z. (2013). Malignant transformation of nasal chondromesenchymal hamartoma in adult: a case report and review of the literature. Histology and Histopathology 28, 337-344.
Lingaas F., Comstock K.E., Kirkness E.F., Sorensen A., Aarskaug T., Hitte C., Nickerson M.L., Moe L., Schmidt L.S., Thomas R., Breen M., Galibert F., Zbar B., Ostrander E.A. (2003). A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd dog. Human Molecular Genetics 12, 3043-3053.
Machida N., Katsuda S., Yamamura H., Kashida Y., Mitsumori K. (2002). Myocardial hamartoma of the right atrium in a dog. Journal of Comparative Pathology 127, 297-300.
Matos A.J., Duarte S., Lopes C., Lopes J.M., Gärtner F. (2007). Splenic hamartomas in a dog. Veterinary Record 161, 308-310.
Mavrikakis I., White V.A., Heran M., Rootman J. (2007). Orbital mesenchymal hamartoma with rhabdomyomatous features. British Journal of Ophthalmology 91, 692-693.
Mcgavin M.D., Henry J. (1972). Canine hepatic vascular hamartoma associated with ascites. Journal of the American Veterinary Medical Association 160, 864-866.
McLean D.I., Haynes H.A. (1993). Cutaneous manifestations of internal malignant disease. In: Fitzpatrick T.B., Eisen A.Z., Wolff K., Freedberg I.M., Austin K.F. (editors). Dermatology in General Medicine. Fourth edition, McGraw-Hill, New York, p. 2237.
Mora L.E., Rodriguez-Reyes A.A., Vera A.M., Rubio R.I., Mayorguin-Ruiz M., Salcedo G. (2012). Congenital smooth muscle hamartoma of the palpebral conjunctiva. Ophthalmic Plastic and Reconstructive Surgery 28, 102-104.
Morton S., Stevens A., Powell R.J. (1998). Basaloid follicular hamartoma, total body hair loss and SLE. Lupus 7, 207-209.
Mudhar H.S., Rogers N.K. (2013). Conjunctival hamartoma with eosinophilia - a novel lesion in a child with PTEN hamartoma syndrome. Graefe's Archive for Clinical and Experimental Ophthalmology 251, 2077-2079.
Njoku C.O., Henry J.D., Cook J.E., Guffy M.M. (1972). Pulmonary vascular hamartoma in a dog. Journal of the American Veterinary Medical Association 161, 378-381.
Proia A.D. (2007). Pigmented hamartoma of the eyelid with apocrine, follicular and sebaceous differentiation. Journal of Cutaneous Pathology 34, 876-881.
Ramanujam T.M., Ramesh J.C., Goh D.W., Wong K.T., Ariffin W.A., Kumar G., Taib N.A. (1999). Malignant transformation of mesenchymal hamartoma of the liver: case report and review of the literature. Journal of Pediatric Surgery 34, 1684-1686.
Read R.W., Burnstine M., Rowland J.M., Zamir E., Rao N.A. (2001). Rhabdomyomatous mesenchymal hamartoma of the eyelid: report of a case and literature review. Ophthalmology 108, 798-804.
Ridley C.M., Smith N. (1981). Generalized hair follicle hamartoma associated with alopecia and myasthenia gravis: report of a second case. Clinical and Experimental Dermatology 6, 283-289.
Roper G.J., Smith M.S., Lueder G.T. (1999). Congenital smooth muscle hamartoma of the conjunctival fornix. American Journal of Ophthalmology 128, 643-644.
Rosenberg A.S., Kirk J., Morgan M.B. (2002). Rhabdomyomatous mesenchymal hamartoma: an unusual dermal entity with a report of two cases and a review of the literature. Journal of Cutaneous Pathology 29, 238-243.
Rubegni P., Risulo M., Sbano P., Buonocore G., Perrone S., Fimiani M. (2003). Encephalocraniocutaneous lipomatosis (Haberland syndrome) with bilateral cutaneous and visceral involvement. Clinical and Experimental Dermatology 28, 387-390.
Sakurai M., Morita T., Kondo H., Uemura T., Haruna A., Shimada A. (2011). Cerebral vascular hamartoma with thrombosis in a dog. Journal of Veterinary Medical Science 73, 1367-1369.
Sanders S.G., Bagley R.S., Gavin P.R., Konzik R.L., Cantor G.H. (2002). Surgical treatment of an intramedullary spinal cord hamartoma in a dog. Journal of the American Veterinary Medical Association 221, 659-661.
Saunders G.K. (2007). Cranial nerve hamartoma in a dog. Veterinary Pathology 44, 253-254.
Sebastianelli M., Mandara M.T., Pavone S., Canal S., Bernardini M. (2013). Thalamic astrocytic hamartoma and associated meningoangiomatosis in a German shepherd dog. Research in Veterinary Science 94, 644-647.
Smith S.H., Van Winkle T. (2001). Cerebral vascular hamartomas in five dogs. Veterinary Pathology 38, 108-112.
Splitter G.A., Rawlings C.A., Casey H.W. (1972). Renal hamartoma in a dog. American Journal of Veterinary Research 33, 273-275.
Takahashi K., Maeda K., Nakamura S., Fujita M., Orima H., Tagawa M., Kuwahara M., Nakashima N., Maita, K. (2000). Pulmonary microcystic hamartoma in an adult dog. Veterinary Pathology 37, 499-501.
Taney K.G., Dubielzig R.R., Trotter T.S., Smith M.M. (2005). Bilateral maxillary periodontal ligament hamartoma in a dog. Journal of Veterinary Dentistry 22, 91-95.
Tucker S.M., Cooper K., Brownschidle S., Wilcox R. (2012). Embryonal (undifferentiated) sarcoma of the liver with peripheral angiosarcoma differentiation arising in a mesenchymal hamartoma in an adult patient. International Journal of Surgical Pathology 20, 297-300.
Wang F.I., Liang S.L., Chen G.H., Chen D.U. (2001). Unilateral concurrence of pyelocaliceal diverticula and intracapsular angiomyolipoma in the kidney of a cat. Journal of Veterinary Diagnostic Investigation 13, 167-169.
Watson A.D., Young K.M., Dubielzig R.R., Biller D.S. (1993). Primary mesenchymal or mixed-cell-origin lung tumors in four dogs. Journal of the American Veterinary Medical Association 202, 968-970.
Yasuno K., Kobayashi R., Ohmuro T., Kamiie J., Sahara H., Shirota K. (2011). Caudal vascular hamartoma accompanied by aberrant arteriovenous structures in a dog. Journal of Veterinary Diagnostic Investigation 23, 1051-105
