Article (Scientific journals)
Catecholamine and HPA axis dysfunction in depression : relationship with suicidal behavior
Pitchot, William; Reggers, Jean; Pinto, Emmanuel et al.
2003In Neuropsychobiology, 47 (3), p. 152-157
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Keywords :
depression; suicide attempt; dopamine; noradrenaline; dexamethasone suppression test; dépression
Abstract :
[en] A large body of evidence suggests a potential role for catecholaminergic function as a possible biological factor in the control of suicidal behavior. Recently, we have used a neuroendocrine strategy to study dopaminergic and noradrenergic activities in depressed suicide attempters. However, some problems are associated with the use of growth hormone (GH) response to catecholaminergic challenge, because GH release could be decreased by a direct effect of corticosteroids at the pituitary level. Therefore, the purpose of the present study was to assess GH response to both apornorphine, a dopaminergic agonist, and clonidine, an alpha2-adrenergic agonist, according to the dexamethasone suppression test (DST) status in a sample of 20 major depressed inpatients with a history of suicide attempt compared with nonattempters. Our results tended to show that hypercortisolemia as assessed by post-DST cortisol values did not inhibit GH response to apornorphine or clonidine, suggesting that hypothalamo-pituitary-adrenal axis overactivity does not explain the impaired GH response to apornorphine in major depressed patients with a history of suicide attempt.
Disciplines :
Neurosciences & behavior
Author, co-author :
Pitchot, William ;  Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Reggers, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > HOSPITALISATION - PSYCHO & PSYCHIATRIE T3 -3E
Pinto, Emmanuel ;  Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Hansenne, Michel  
Ansseau, Marc ;  Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Language :
English
Title :
Catecholamine and HPA axis dysfunction in depression : relationship with suicidal behavior
Publication date :
2003
Journal title :
Neuropsychobiology
ISSN :
0302-282X
eISSN :
1423-0224
Publisher :
Karger, Basel, Switzerland
Volume :
47
Issue :
3
Pages :
152-157
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 July 2015

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