[en] Immunosenescence as complex modifications of immunity with age could be related to the so-called frailty syndrome of elderly leading to an inadequate response to minimal aggression. Functional decline, the loss of ability to perform activities of daily living, is related to the decrease in physiological reserves and frailty and is a frequent outcome of hospitalization in older patients. Links between immunosenescence and frailty were explored and 20 immunological parameters were affected in seniors with functional decline. IGF-1, thymopoeisis and telomere length were part of these markers. A strong relationship between insulin-like growth factor-1 (IGF-1) and thymic ouput was evidenced. IGF-1, mediator of GH, was subsequently shown to induce IL-7 secretion in cultured primary human thymic epithelial cells (TECs). We are also exploring the ‘stress hypothesis’ according which an acute stress is the discriminator revealing a frailty susceptility. GH can counteract the deleterious immunosuppressive effect of stress-induced steroids. Under non-stressing conditions, the immunosenescent system preserves physiological responses, while in stressing conditions, the combination of immunosenescence and a defect in somatotrope axis might lead to functional decline.
Research Center/Unit :
GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège
Somatotrope GHRH/GH/IGF-1 axis at the crossroad between immunosenescence and elder frailty
Publication date :
2015
Journal title :
Annals of the New York Academy of Sciences
ISSN :
0077-8923
eISSN :
1749-6632
Publisher :
New York Academy of Sciences, New York, United States - New York
Special issue title :
Neuroimmunomodulation in Health and Disease
Volume :
1351
Pages :
61-67
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Caregiver
Funders :
DGTRE - Région wallonne. Direction générale des Technologies, de la Recherche et de l'Énergie F.R.S.-FNRS - Fonds de la Recherche Scientifique Fonds Léon Fredericq
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