HIV transmission; phylogenetic analysis; forensic investigation; epidemiological linkage
Abstract :
[en] Objective: To test the a priori hypothesis of HIV-1 transmission from one suspect to six recipients in a criminal case. Methods: Partial pol and/or env sequences were obtained for at least two samples of the suspect and the victims. Appropriate local controls were sampled based on epidemiological and subtype criteria. Phylogenetic testing was performed using different reconstruction methods. Results: Phylogenetic analyses consistently inferred a monophyletic cluster for the suspect and victim samples in both genome regions. This was highly supported by parametric and non-parametric bootstrapping techniques. Moreover, the controls most closely related to the suspect-victim cluster had a similar geographical origin to the suspect. Conclusions: Taking into account the limitations on the conclusions that can be drawn from molecular investigations we could infer that our molecular data is consistent with a scenario of multiple HIV transmission between suspect and victims.
Disciplines :
Immunology & infectious disease
Author, co-author :
Lemey, Philippe; Katholieke Universiteit Leuven - KUL > Rega inst.
Van Dooren, Sonia; Univ. Antwerp > Dept.Social Med and Epidemiol > 2020 Antwerp
Van Laethem, Kristel
Schrooten, Yoeri
Derdelinckx, Inge
Goubau, Patrick
Brun-Vezinet, Françoise
Vaira, Dolorès ; Centre Hospitalier Universitaire de Liège - CHU > Immuno-hématologie
Vandamme, Anne-Mieke; Univ.Antwerp > Dept. Social Med and Epidemiol. > 2020 Antwerp
Language :
English
Title :
Molecular testing of multiple HIV-1 transmissions in a criminal case
Publication date :
14 October 2005
Journal title :
AIDS
ISSN :
0269-9370
eISSN :
1473-5571
Publisher :
Lippincott Williams & Wilkins, Philadelphia, United States - Pennsylvania
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