Serological cross-reactivity between Merkel cell polyomavirus and two closely related chimpanzee polyomaviruses.

[en] Phylogenetic analyses based on the major capsid protein sequence indicate that Merkel cell polyomavirus (MCPyV) and chimpanzee polyomaviruses (PtvPyV1, PtvPyV2), and similarly Trichodysplasia spinulosa-associated polyomavirus (TSPyV) and the orangutan polyomavirus (OraPyV1) are closely related. The existence of cross-reactivity between these polyomaviruses was therefore investigated. The findings indicated serological identity between the two chimpanzee polyomaviruses investigated and a high level of cross-reactivity with Merkel cell polyomavirus. In contrast, cross-reactivity was not observed between TSPyV and OraPyV1. Furthermore, specific antibodies to chimpanzee polyomaviruses were detected in chimpanzee sera by pre-incubation of sera with the different antigens, but not in human sera.

Disciplines :

Microbiology

Author, co-author :

Nicol, Jérôme ; Université de Liège > Département des sciences biomédicales et précliniques > Virologie

Liais, Etienne

Potier, Romain

Mazzoni, Elisa

Tognon, Mauro

Coursaget, Pierre

Touze, Antoine

Language :

English

Title :

Serological cross-reactivity between Merkel cell polyomavirus and two closely related chimpanzee polyomaviruses.

Publication date :

2014

Journal title :

PLoS ONE

eISSN :

1932-6203

Publisher :

Public Library of Science, United States - California

Volume :

Issue :

Pages :

e97030

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 05 June 2015

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