Reference : Modeling microdamage behavior of cortical bone
Scientific journals : Article
Engineering, computing & technology : Multidisciplinary, general & others
Modeling microdamage behavior of cortical bone
Donaldson, Finn [> >]
Ruffoni, Davide mailto [Université de Liège > Département d'aérospatiale et mécanique > Mécanique des matériaux biologiques et bioinspirés >]
Schneider, Philipp [> >]
Alina, Levchuk [> >]
Zwahlen, Alexander [> >]
Pankaj, Pankaj [> >]
Mueller, Ralph [> >]
Biomechanics and Modeling in Mechanobiology
Yes (verified by ORBi)
[en] Multilevel finite element analysis; Bone microstructure; Cortical porosity; Microdamage; Bone quality FINITE-ELEMENT-ANALYSIS; AGE-RELATED-CHANGES; 3D CRACK-GROWTH TRABECULAR-BONE; FEMORAL-NECK; LEVEL SETS; SYNCHROTRON-RADIATION MICROCRACK INITIATION; COMPUTED-TOMOGRAPHY; FRACTURE-TOUGHNESS Biophysics; Engineering Biophysics; Engineering ; Biomedical Muller ; Ralph/A-1198-2008 Muller ; Ralph/0000-0002-5811-7725 Swiss National Supercomputing Centre (CSCS ; Lugano ; Switzerland) Carnegie Trust for the Universities of Scotland The authors acknowledge the Swiss National Supercomputing Centre (CSCS Lugano ; Switzerland). F.D. gratefully acknowledges support from the Carnegie Trust for the Universities of Scotland ; P. S. from the Swiss National Science Foundation and A. L. from the Whitaker Foundation. 72 1 Biomech. Model. Mechanobiol. AQ9XD ISI:000343210900006
[en] Bone is a complex material which exhibits several hierarchical levels of structural organization. At the submicron-scale, the local tissue porosity gives rise to discontinuities in the bone matrix which have been shown to influence damage behavior. Computational tools to model the damage behavior of bone at different length scales are mostly based on finite element (FE) analysis, with a range of algorithms developed for this purpose. Although the local mechanical behavior of bone tissue is influenced by microstructural features such as bone canals and osteocyte lacunae, they are often not considered in FE damage models due to the high computational cost required to simulate across several length scales, i.e., from the loads applied at the organ level down to the stresses and strains around bone canals and osteocyte lacunae. Hence, the aim of the current study was twofold: First, a multilevel FE framework was developed to compute, starting from the loads applied at the whole bone scale, the local mechanical forces acting at the micrometer and submicrometer level. Second, three simple microdamage simulation procedures based on element removal were developed and applied to bone samples at the submicrometerscale, where cortical microporosity is included. The present microdamage algorithm produced a qualitatively analogous behavior to previous experimental tests based on stepwise mechanical compression combined with in situ synchrotron radiation computed tomography. Our results demonstrate the feasibility of simulating microdamage at a physiologically relevant scale using an image-based meshing technique and multilevel FE analysis; this allows relating microdamage behavior to intracortical bone microstructure.

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