[en] Background and aim: The present study was designed to explore anti-diabetic and hepato-protective potentials of Fraxinus angustifolia leaf (FAL) and bark (FAB) extracts in vivo.
Kuzuya T, Nakagawa S, Satoh J, Kanazawa Y, Iwamoto Y, Kobayashi M, Nanjo K, Sasaki A, SeinoY, Ito C et al. Report of the committee on the classification and diagnostic criteria of diabetes mellitus. Diabetes Res Clin Pr 2002; 55: 65-85.
Chaudhary P, Goel B, Ghosh AK. Anti-diabetic activity of Adina cordifolia (Roxb) leaves in alloxan induced diabetic rats. Asian Pac J Trop Biomed 2012; 2: 1630-1632.
Puranik N, Kammar KF, Devi S. Anti-diabetic activity of Tinospora cordifolia (Willd.) in streptozotocin diabetic rats; does it act like sulfonylureas? Turk J Med Sci 2010; 40: 265-270.
Newman DJ, Cragg GM, Snader KM, The influence of natural products upon drug discovery. Nat Prod Rep 2000; 17: 215-234.
Shan S, Zhenyuan S, Cotler SJ, Cho M. Biomechanics and functionality of hepatocytes in liver cirrhosis. J Biomech 2014; 47: 2205-2210.
Barber DJ, Fairhurst S, Horton AA. Effect of old age on paracetamol-induced lipid peroxidation in rat liver (Glutathione; gerontological aspects of drug metabolism). Toxicol Lett 1983; 15: 283-287.
Castro JA, Acosta ND, Deferreyra EC, De Castro CR, Diaz Gomez MI, De Fenos OM. Studies on thioacetamide-induced liver necrosis. Toxicol Appl Pharm 1974; 79-86.
Hartung R, Cornish HH, Cosmet FD. Acute and short-term oral toxicity of 2-N-ethylaminoethanol in rats. Toxicol Lett 1969; 7: 595-602.
Ahmed AS, Elgorashi EE, Moodley N, McGaw LJ, Naidoo V, Eloff JN. The antimicrobial, antioxidative, anti-inflammatory activity and cytotoxicity of different fractions of four South African Bauhinia species used traditionally to treat diarrhea. J Ethnopharmacol 2012; 143: 826-839.
Allali H, Benmehdi H, Dib MA, Tabti B, Ghalem S, Benabadji N. Phytotherapy of diabetes in west Algeria. Asian J Chem 2008; 20: 2701-2710.
Boudjelal A, Henchiri C, Siracusa L, Sari M, Ruberto G. Compositional analysis and in vivo anti-diabetic activity of wild egyptian Marrubium vulgare L. infusion. Fitoterapia 2012; 83: 286-292.
Maghrani M, Zeggwagh NA, Lemhadri A, El Amraoui M, Michel JB, Eddouks M. Study of the hypoglycaemic activity of Fraxinus excelsior and Silybum marianum in an animal model of type 1 diabetes mellitus. J Ethnopharmacol 2004; 91: 309-316.
Goodman SM, Hobbs JJ. The ethnobotany of the Egyptian eastern desert: a comparison of common plant usage between two culturally distinct Bedouin groups. J Ethnopharmacol 1988; 23: 73-89.
Bellakhdar J, Claisse R, Fleurentin J, Younos C. Repertory of standard herbal drugs in the Moroccan pharmacopoeia. J Ethnopharmacol 1991; 35: 123-143.
Martin G, Iserin P. Les plantes par classe therapeutique. Phytotherapy 1993; 40: 29-31 (in French).
Legssyer A, Mekhfi H, Dassouli A, Serhrouchni M, Benjelloun W. Phytotherapy of hypertension and diabetes in oriental Morocco. J Ethnopharmacol 1997; 58: 45-54.
Montreau FR. Sur le dosage des composés phénoliques totaux dans les vins par la méthode Folin-Ciocalteau. Connaiss Vigne Vin 1972; 24: 397-404 (in French).
Mimica-Dukic IN, Ivanec-Tumbas R, Popovic IM, Gasic O. The content and composition of essential oil of Hypericum perforatum from Serbia. Pharm Pharmacol Lett 1997; 8: 26-28.
Singh R, Singh RK, Tripathi AK, Cornflissen G, Schwartzkopff O, Otsuka K, Halberg F. Chronomics of circulating plasma lipid peroxides and anti-oxidant enzymes and other related molecules in cirrhosis of liver. Biomed Pharmacother 2005; 59: 229-235.
Hasenah A, Houghton PJ, Soumyanath A. Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus. J Ethnopharmacol 2006; 107: 449-455.
Yeh SI, Hu MI. Antioxidant and pro-oxidant effect of lycopene in comparison with β carotene on oxidant induced damage in Hs 68 cells. J Nutr Biochem 2000; 11: 548-554.
Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thio-barbituric acid reaction. Anal Biochem 1979; 95: 351-358.
Azofeifa G, Quesada S, Perez AM, Vaillant F, Michel A. Pasteurization of blackberry juice preserves polyphenoldependent inhibition for lipid peroxidation and intracellular radicals. J Food Compos Anal 2015; 42: 56-62.
Gaedcke F. Fraxinus. In: Hänsel R, Keller K, Rimpler H, Schneider G, editors. Hagers Handbuch der Pharmazeutischen Praxis. 5th ed. Berlin, Germany: Springer-Verlag; 1993. pp. 188-200 (in German).
Kostova I, Iossifova T. Chemical components of Fraxinus species. Fitoterapia 2007; 78: 85-106.
Atmani D, Chaher N, Berboucha M, Ayouni K, Lounis H, Boudaoud H, Debbache N, Atmani D. Antioxidant capacity and phenol content of selected Algerian medicinal plants. Food Chem 2009; 112: 303-309.
Slater TF. A note on the relative toxic activities of tetrachloromethane and trichloro-fluoro-methane on the rat. Biochem Pharmacol 1965; 14: 178-181.
Durmuş M, Yilmaz HR, Uz E, Özçelik N. The effect of caffeic acid phenethyl ester (CAPE) treatment on levels of MDA, NO and antioxidant enzyme activities in retinas of streptozotocininduced diabetic rats. Turk J Med Sci 2008; 38: 525-530.
Kröncke KD, Fehsel K, Sommer A, Rodriguez ML, Kolbbachofen V. Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage. Biol Chem 1995; 376: 179-185.
Berboucha M, Ayouni K, Atmani D, Atmani D, Benboubetra M. Kinetic study on the inhibition of xanthine oxidase by extracts from two selected Algerian plants traditionally used for the treatment of inflammatory diseases. J Med Food 2010; 13: 896-904.
Brahmachari, G. Natural Products: Chemistry, Biochemistry and Pharmacology. 1st Ed. New Delhi, India: Narosa Publishing House Pvt. Ltd; 2009.
Palsamy P, Subramanian S. Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin nicotinamide induced experimental diabetic rats. Biomed Pharmacother 2008; 62: 598-605.
Kumar R, Pate DK, Prasad SK, Sairam K, Hemalatha S. Antidiabetic activity of alcoholic leaves extract of Alangium lamarckii Thwaites on streptozotocin-nicotinamide induced type 2 diabetic rats. Asian Pac J Trop Med 2011; 904-909.
Tarling CA, Woods K, Zhang R, Brastianos HC, Brayer GD, Andersen RJ, Withers SG. The search for novel human pancreatic α-amylase inhibitors: high-throughput screening of terrestrial and marine natural product extracts. Chem Bio Chem 2008; 9: 433-438.
Kim JS, Kwon CS, Son KH. Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. Biosc Biotechnol Biochem 2000; 64: 2458-2461.
Sallie R, King R, Silva AE, Smith H, Tibbs C, Johnson P, Williams R. Prevalence of hepatitis "C" virus carriage in non-selected, otherwise healthy patients attending general practitioners in South London. J Hepatol 1991; 13: 167.
Packer JE, Slater TF, Willson RL. Reactions of the carbon tetrachloride-related peroxyl free radical (CCl3O2.) with amino acids: pulse radiolysis evidence. Life Sci 1978; 23: 2617-2620.
Chedella HK, Alluri R, Ghanta KM. hepatoprotective and antioxidant effect of Ecbolium viride (Forssk.) Alston roots against paracetamol-induced hepatotoxicity in albino wistar rats. J Pharm Res 2013; 7: 496-501.
Vande Straat R, Ries JV, Vermeulen NPE. Role of hepatic microsomal and purified cytochrome P-450 in one-electron reduction of two quinone imines and concomitant reduction of molecular oxygen. Biochem Pharmacol 1987; 36: 613-619.
Pesh-Imam M, Recknagel RO. Lipid peroxidation and the concept of anti oxygenic potential: Vitamin E changes in acute experimental CCl4-, BrCCl3-, and ethanol-induced liver injury. Toxicol Appl Pharm 1977; 42: 463-475.
Aldridge WN. Mechanisms of toxicity: new concepts are required in toxicology. Trends Pharmacol Sci 1981; 2: 228-231.
Asayama K, Uchida N, Nwakene T, Hayashibe H, Dobashi K, Amemia S, Kato K, Nakazawa S. Antioxidants in the serum of children with insulin-dependent diabetes mellitus. Free Radical Bio Med 1993; 15: 597-602.
Judah JD. Biochemical disturbances in liver injury. Brit Med Bull 1969; 25: 274-277.
McLean AEM, Nuttell L. An in vitro model of liver injury using paracetamol treatment of liver slices and prevention of injury by some antioxidants. Biochem Pharmacol 1978; 27: 425.
Yayla M, Halici Z, Unal B, Bayir Y, Akpinar E, Gocer F. Protective effect of Et-1 receptor antagonist bosentan on paracetamolinduced acute liver toxicity in rats. Eur J Pharmacol 2014; 726: 87-95.
