Reference : Quality assurance for the EORTC 22071¿26071 study: dummy run prospective analysis.
Scientific journals : Article
Human health sciences : Oncology
Quality assurance for the EORTC 22071¿26071 study: dummy run prospective analysis.
Fairchild, Alysa [> >]
Langendijk, Johannes A [> >]
Nuyts, Sandra [> >]
Scrase, Christopher [> >]
Tomsej, Milan [> >]
Schuring, Danny [> >]
GULYBAN, Akos mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiothérapie >]
Ghosh, Sunita [> >]
Weber, Damien C. [> >]
Budach, Wilfried [> >]
Radiation oncology (London, England)
[en] PurposeThe phase III 22071¿26071 trial was designed to evaluate the addition of panitumumab to adjuvant chemotherapy plus intensity modulated radiotherapy (IMRT) in locally advanced resected squamous cell head and neck cancer. We report the results of the dummy run (DR) performed to detect deviations from protocol guidelines.Methods and MaterialsDR datasets consisting of target volumes, organs at risk (OAR) and treatment plans were digitally uploaded, then compared with reference contours and protocol guidelines by six central reviewers. Summary statistics and analyses of potential correlations between delineations and plan characteristics were performed.ResultsOf 23 datasets, 20 (87.0\%) GTVs were evaluated as acceptable/borderline, along with 13 (56.5\%) CTVs and 10 (43.5\%) PTVs. All PTV dose requirements were met by 73.9 of cases. Dose constraints were met for 65.2-100 of mandatory OARs. Statistically significant correlations were observed between the subjective acceptability of contours and the ability to meet dose constraints for all OARs (p¿¿¿0.01) except for the parotids and spinal cord. Ipsilateral parotid doses correlated significantly with CTV and PTV volumes (p¿¿¿0.05).ConclusionsThe observed wide variations in treatment planning, despite strict guidelines, confirms the complexity of development and quality assurance of IMRT-based multicentre studies for head and neck cancer.

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Fairchild et al. - 2014 - Quality assurance for the EORTC 22071¿26071 study dummy run prospective analysis.pdfPublisher postprint875.57 kBView/Open

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