Reference : Development of aptamer-based radiopharmaceuticals for targeted cancer imaging and therapy
Scientific congresses and symposiums : Poster
Life sciences : Biochemistry, biophysics & molecular biology
Development of aptamer-based radiopharmaceuticals for targeted cancer imaging and therapy
Gijs, Marlies mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Aerts, An mailto []
Impens, Nathalie mailto []
Baatout, Sarah mailto []
Luxen, André mailto [Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse >]
First Symposium on Precision Image-Guided Small Animal RadioTherapy
04-03-2013 to 05-03-2013
The Netherlands
[en] aptamer ; cancer ; radiopharmaceutical
[en] This SELEX experiment, for the selection of HER2 targeting aptamers, resulted in 26 selected RNA aptamers for further individual evaluation. Up till now, we
were able to identify two aptamers that show binding to HER2 overexpressing SK-OV-3 cancer cells. In addition, we were able to generate silenced SK-OV-3
cells with minimal remaining HER2 levels, which will be used to obtain more information regarding the binding specificity of the selected aptamers.
Centre de Recherches du Cyclotron - CRC

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