Reference : Synthesis of lutetium-carrying oligonucleotides for targeted cancer therapy and imaging
Scientific congresses and symposiums : Poster
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/182548
Synthesis of lutetium-carrying oligonucleotides for targeted cancer therapy and imaging
English
Gijs, Marlies mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Aerts, An mailto [Belgian Nuclear Research Centre, SCK•CEN > Radiobiology Unit > > >]
Impens, Nathalie mailto [Belgian Nuclear Research Centre, SCK•CEN > Radiobiology Unit > > >]
Baatout, Sarah mailto [Belgian Nuclear Research Centre, SCK-CEN > Radiobiology Unit > > >]
Dewilde, Sylvia mailto [University of Antwerp > Department of Biomedical Sciences, > > >]
Luxen, André mailto [Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse >]
27-Jun-2012
No
International
13th Tetrahedron Symposium
26-06-2012 to 29-06-2012
Amsterdam
The Netherlands
[en] lutetium ; oligonucleotides ; cancer
[en] In this study, different techniques were evaluated to test the binding properties of an anti-HER3 aptamer to its target on cells or as pure protein. Furthermore, the aptamer was successfully coupled to DOTA-NHS ester and labelled with natural occurring lutetium. However, for a better yield, the coupling and labelling reactions need further optimization.
Centre de Recherches du Cyclotron - CRC
http://hdl.handle.net/2268/182548

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