Efficient one-pot synthesis of trans- Pt(II)(salicylaldimine)(4-picoline)Cl complexes: Effective agents for enhanced expression of p53 tumor suppressor genes

Rahman, Faiz-Ur; Ali, Amjad; Guo, Rong; Wang, Wei-Kun; Wang, Hui; Li, Zhan-Ting; Lin, Yuejian; Zhang, Dan-Wei

doi:10.1039/c5dt01098e

Article (Scientific journals)

Efficient one-pot synthesis of trans- Pt(II)(salicylaldimine)(4-picoline)Cl complexes: Effective agents for enhanced expression of p53 tumor suppressor genes

Rahman, Faiz-Ur; Ali, Amjad; Guo, Rong et al.

2015 • In Dalton Transactions

Peer reviewed

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https://hdl.handle.net/2268/182211

DOI
10.1039/c5dt01098e

PubMed
25939861

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Abstract :

[en] A series of trans-Pt(II)(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78‒87% yield using one-pot procedure from commercially available precursors. The structures of these complexes were characterized by 1H, 19F and 13C NMR spectroscopy, HRMS (ESI) as well as single crystal X-ray analysis. Bioactivity investigations including bio-assay, time- and dosedependent, cell cycle progression study, caspase 3 and 9 apoptosis marker assay and DNA interaction using pBR322 plasmid DNA by gel electrophoresis were performed. The results indicated that the complexes showed promising in vitro cytotoxicity in MCF-7 and A549 cancer cell lines. Moreover these complexes enhanced the expression of p53 tumor suppressor gene family members such as p63 and p73.

Disciplines :

Chemistry

Author, co-author :

Rahman, Faiz-Ur

Ali, Amjad ; Université de Liège > Département de pharmacie > Chimie médicale

Guo, Rong

Wang, Wei-Kun

Wang, Hui

Li, Zhan-Ting

Lin, Yuejian

Zhang, Dan-Wei

Language :

English

Title :

Efficient one-pot synthesis of trans- Pt(II)(salicylaldimine)(4-picoline)Cl complexes: Effective agents for enhanced expression of p53 tumor suppressor genes

Publication date :

23 April 2015

Journal title :

Dalton Transactions

ISSN :

1477-9226

eISSN :

1477-9234

Publisher :

Royal Society of Chemistry (RSC), Cambridge, United Kingdom

Peer reviewed :

Peer reviewed

Available on ORBi :

since 01 June 2015

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