Article (Scientific journals)
Efficient one-pot synthesis of trans- Pt(II)(salicylaldimine)(4-picoline)Cl complexes: Effective agents for enhanced expression of p53 tumor suppressor genes
Rahman, Faiz-Ur; Ali, Amjad; Guo, Rong et al.
2015In Dalton Transactions
Peer reviewed
 

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Abstract :
[en] A series of trans-Pt(II)(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78‒87% yield using one-pot procedure from commercially available precursors. The structures of these complexes were characterized by 1H, 19F and 13C NMR spectroscopy, HRMS (ESI) as well as single crystal X-ray analysis. Bioactivity investigations including bio-assay, time- and dosedependent, cell cycle progression study, caspase 3 and 9 apoptosis marker assay and DNA interaction using pBR322 plasmid DNA by gel electrophoresis were performed. The results indicated that the complexes showed promising in vitro cytotoxicity in MCF-7 and A549 cancer cell lines. Moreover these complexes enhanced the expression of p53 tumor suppressor gene family members such as p63 and p73.
Disciplines :
Chemistry
Author, co-author :
Rahman, Faiz-Ur
Ali, Amjad ;  Université de Liège > Département de pharmacie > Chimie médicale
Guo, Rong
Wang, Wei-Kun
Wang, Hui
Li, Zhan-Ting
Lin, Yuejian
Zhang, Dan-Wei
Language :
English
Title :
Efficient one-pot synthesis of trans- Pt(II)(salicylaldimine)(4-picoline)Cl complexes: Effective agents for enhanced expression of p53 tumor suppressor genes
Publication date :
23 April 2015
Journal title :
Dalton Transactions
ISSN :
1477-9226
eISSN :
1477-9234
Publisher :
Royal Society of Chemistry (RSC), Cambridge, United Kingdom
Peer reviewed :
Peer reviewed
Available on ORBi :
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