Synthesis and anticancer activities of a novel class of mono- and di-metallic Pt(II)(salicylaldiminato)- (DMSO or Picolino)Cl complexes

Rahman, Faiz-Ur; Ali, Amjad; Guo, Rong; Zhang, Yun-Chang; Wang, Hui; Lia, Zhan-Ting; Zhang, Dan-Wei

doi:10.1039/c4dt03018d

Article (Scientific journals)

Synthesis and anticancer activities of a novel class of mono- and di-metallic Pt(II)(salicylaldiminato)- (DMSO or Picolino)Cl complexes

Rahman, Faiz-Ur; Ali, Amjad; Guo, Rong et al.

2015 • In Dalton Transactions

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/182210

DOI
10.1039/c4dt03018d

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25510629

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Abstract :

[en] A series of novel Pt(II) complexes [cis- and trans-Pt(II)(salicylaldimine)(DMSO)Cl (C-1), trans-Pt(II)(salicylaldimine)( 4-picoline)Cl (C-2), Pt(II)(salicylaldimine)Cl (C-3), trans- and cis/trans-Pt2(II)(salicylaldimine) (DMSO)2Cl2 (C-4), trans-Pt2(II)(salicylaldimine)(4-picoline)2Cl2 (C-5) was synthesized and characterized. The structures of C-1-cis, C-1-trans and C-3 were determined using a single crystal X-ray analysis. This class of Pt(II) complexes has been studied for their in vitro cytotoxicity in multiple human cancer cell lines, including breast (MCF-7), liver (HepG2), lung (A549), colon (HCT116) and cervical (Hela) cancers. C-1- trans, C-2 and C-4-trans showed significant cytotoxicity to these cancer cells comparable to cisplatin. A time- and dose-dependent MTT assay revealed that these complexes can suppress cell viability and cell proliferation. Mechanistically these complexes induced pro-apoptotic gene expression such as BAX, PUMA and NOXA and thereby enhanced apoptosis. Moreover, PARP cleavage in a dose-dependent manner indicated their cytotoxic effect against cancer cells. Apoptosis of cancer cells occurred through apoptotic pathways as explained by the cytometry analysis. The DNA unwinding properties of these active Pt(II) complexes were studied by gel electrophoresis using pBR322 plasmid DNA as a target. Changes in the morphology of cancer cells were also observed upon the addition of C-1-trans, C-2 and C-4-trans.

Disciplines :

Chemistry

Author, co-author :

Rahman, Faiz-Ur

Ali, Amjad ; Université de Liège > Département de pharmacie > Chimie médicale

Guo, Rong

Zhang, Yun-Chang

Wang, Hui

Lia, Zhan-Ting

Zhang, Dan-Wei

Language :

English

Title :

Synthesis and anticancer activities of a novel class of mono- and di-metallic Pt(II)(salicylaldiminato)- (DMSO or Picolino)Cl complexes

Publication date :

08 February 2015

Journal title :

Dalton Transactions

ISSN :

1477-9226

eISSN :

1477-9234

Publisher :

Royal Society of Chemistry (RSC), Cambridge, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 01 June 2015

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