Biotechnological uses of RNAi in plants: Risk assessment considerations

Food/feed safety; Gene silencing; Genetically modified organism (GMO); Nontarget organism (NTO); Off-target gene; Plant breeding; Note; RNA interference

Abstract :

[en] RNAi offers opportunities to generate new traits in genetically modified (GM) plants. Instead of expressing novel proteins, RNAi-based GM plants reduce target gene expression. Silencing of off-target genes may trigger unintended effects, and identifying these genes would facilitate risk assessment. However, using bioinformatics alone is not reliable, due to the lack of genomic data and insufficient knowledge of mechanisms governing mRNA-small (s)RNA interactions. © 2014 Elsevier Ltd.

Disciplines :

Phytobiology (plant sciences, forestry, mycology...)
Biotechnology

Author, co-author :

Casacuberta, J. M.; Center for Research in Agricultural Genomics, Consejo Superior de Investigaciones Científicas-Institut de Recerca i Tecnologia, Agroalimentàries-Universitat Autònoma de Barcelona-Universitat de Barcelona, Campus Universitat Autònoma de Barcelona, Bellaterra - Cerdanyola del Vallès, Barcelona, Spain

Devos, Y.; European Food Safety Authority, Via Carlo Magno 1/A, Parma, Italy

du Jardin, Patrick ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie végétale

Ramon, M.; European Food Safety Authority, Via Carlo Magno 1/A, Parma, Italy

Vaucheret, H.; INRA, Institut Jean-Pierre Bourgin, Saclay Plant Sciences, Versailles, France, AgroParisTech, Institut Jean-Pierre Bourgin, Saclay Plant Sciences, Versailles, France

Nogué, F.; INRA, Institut Jean-Pierre Bourgin, Saclay Plant Sciences, Versailles, France, AgroParisTech, Institut Jean-Pierre Bourgin, Saclay Plant Sciences, Versailles, France

Language :

English

Title :

Biotechnological uses of RNAi in plants: Risk assessment considerations

Publication date :

2015

Journal title :

Trends in Biotechnology

ISSN :

0167-7799

eISSN :

1879-3096

Publisher :

Elsevier

Volume :

Issue :

Pages :

145-147

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 28 May 2015

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Bibliography

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