Asa SL, Kovacs K, Stefaneanu L, Horvath E, Billestrup N, Gonzalez-Manchon C & Vale W 1990 Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 193 232-235. (doi:10.3181/00379727-193-3-RC1)
Asa SL, Kovacs K, Stefaneanu L, Horvath E, Billestrup N, Gonzalez-Manchon C & Vale W 1992 Pituitary adenomas in mice transgenic for growth hormone-releasing hormone. Endocrinology 131 2083-2089. (doi:10.1210/endo.131.5.1425411)
AvRuskin TW, Sau K, Tang S & Juan C 1973 Childhood acromegaly: successful therapy with conventional radiation and effects of chlorpromazine on growth hormone and prolactin secretion. Journal of Clinical Endocrinology and Metabolism 37 380-388. (doi:10.1210/jcem-37-3-380)
Beckers A, Aaltonen LA, Daly AF & Karhu A 2013 Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene. Endocrine Reviews 34 239-277. (doi:10.1210/er.2012-1013)
Borson-Chazot F, Garby L, Raverot G, Claustrat F, Raverot V, Sassolas G & GTE Group 2012 Acromegaly induced by ectopic secretion of GHRH: a review 30 years after GHRH discovery. Annales d'Endocrinologie 73 497-502. (doi:10.1016/j.ando.2012.09.004)
Brar AK, Brinster RL & Frohman LA 1989 Immunohistochemical analysis of human growth hormone-releasing hormone gene expression in transgenic mice. Endocrinology 125 801-809. (doi:10.1210/endo-125-2-801)
Chahal HS, Trivellin G, Leontiou CA, Alband N, Fowkes RC, Tahir A, Igreja SC, Chapple JP, Jordan S, Lupp A et al. 2012 Somatostatin analogs modulate AIP in somatotroph adenomas: the role of the ZAC1 pathway. Journal of Clinical Endocrinology and Metabolism 97 1-10. (doi:10.1210/jc.2012-1111)
Collins BJ, Szabo M & Cuttler L 1996 Differential desensitization response of the neonatal and adult rat somatotroph to growth hormone-releasing hormone and phorbol ester. Molecular and Cellular Endocrinology 117 75-81. (doi:10.1016/0303-7207(95)03731-4)
Coutant R & Bouhours-Nouet N 2012 Endocrine control and regulation of growth hormone: an overview. In Handbook of Growth and Growth Monitoring in Health and Disease, pp 73-92. Ed VR Preedy. New York, NY: Spinger ScienceCBusiness Media, LLC.
Cuevas-Ramos D & Fleseriu M 2014 Somatostatin receptor ligands and resistance to treatment in pituitary adenomas. Journal of Molecular Endocrinology 52 R223-R240. (doi:10.1530/JME-14-0011)
Cuttler L, Collins BJ, Marone PA & Szabo M 1993 The effect of isobutylmethylxanthine, forskolin, and cholera toxin on growth hormone release from pituitary cell cultures of perinatal and mature rats. Endocrine Research 19 33-46. (doi:10.3109/07435809309035406)
Cuttler L, Collins BJ & Szabo M 1995 Ontogeny of the GH response to phorbol ester and phospholipase C in rat pituitary cells. Journal of Endocrinology 145 307-314. (doi:10.1677/joe.0.1450307)
Daly AF, Tichomirowa MA, Petrossians P, Heliövaara E, Jaffrain-Rea M-L, Barlier A, Naves LA, Ebeling T, Karhu A, Raappana A et al. 2010 Clinical characteristics and therapeutic responses in patients with germ-line AIP mutations and pituitary adenomas: an international collaborative study. Journal of Clinical Endocrinology and Metabolism 95 E373-E383. (doi:10.1210/jc.2009-2556)
Daniel A, d'Emden M & Duncan E 2013 Pituitary gigantism treated successfully with the growth hormone receptor antagonist, pegvisomant. Internal Medicine Journal 43 345-347. (doi:10.1111/imj.12077)
Davies JH & Cheetham T 2014 Investigation and management of tall stature. Archives of Disease in Childhood 99 772-777. (doi:10.1136/archdischild-2013-304830)
Dubuis JM, Deal CL, Drews RT, Goodyer CG, Lagace G, Asa SL, Van Vliet G & Collu R 1995Mammosomatotroph adenoma causing gigantismin an 8-year old boy: a possible pathogenetic mechanism. Clinical Endocrinology 42 539-549. (doi:10.1111/j.1365-2265.1995.tb02675.x)
Eugster EA & Pescovitz OH 1999 Gigantism. Journal of Clinical Endocrinology and Metabolism 84 4379-4384. (doi:10.1210/jcem.84.12.6222)
Garby L, Caron P, Claustrat F, Chanson P, Tabarin A, Rohmer V, Arnault G, Bonnet F, Chabre O, Christin-Maitre S et al. 2012 Clinical characteristics and outcome of acromegaly induced by ectopic secretion of growth hormone-releasing hormone (GHRH): a French nationwide series of 21 cases. Journal of Clinical Endocrinology and Metabolism 97 2093-2104. (doi:10.1210/jc.2011-2930)
Goldenberg N, Racine MS, Thomas P, Degnan B, Chandler W & Barkan A 2008 Treatment of pituitary gigantism with the growth hormone receptor antagonist pegvisomant. Journal of Clinical Endocrinology and Metabolism 93 2953-2956. (doi:10.1210/jc.2007-2283)
Hammer RE, Brinster RL, Rosenfeld MG, Evans RM & Mayo KE 1985 Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth. Nature 315 413-416. (doi:10.1038/315413a0)
Hastings PJ, Ira G & Lupski JR 2009 A microhomology-mediated breakinduced replication model for the origin of human copy number variation. PLoS Genetics 5 e1000327. (doi:10.1371/journal.pgen. 1000327)
de Herder WW 2015 The history of acromegaly. Neuroendocrinology. (In Press) (doi:10.1159/000371808)
Hurxthal LM 1961 Pituitary gigantism in a child five years of age: effect of x-radiation, estrogen therapy and self-imposed starvation diet during an eleven-year period. Journal of Clinical Endocrinology and Metabolism 21 343-353. (doi:10.1210/jcem-21-3-343)
Jaffrain-Rea ML, Angelini M, Gargano D, Tichomirowa MA, Daly AF, Vanbellinghen JF, D'Innocenzo E, Barlier A, Giangaspero F, Esposito V et al. 2009 Expression of aryl hydrocarbon receptor (AHR) and AHR-interacting protein in pituitary adenomas: pathological and clinical implications. Endocrine-Related Cancer 16 1029-1043. (doi:10.1677/ERC-09-0094)
Jaffrain-Rea ML, Rotondi S, Turchi A, Occhi G, Barlier A, Peverelli E, Rostomyan L, Defilles C, AngeliniM, OlivaMA et al. 2013 Somatostatin analogues increase AIP expression in somatotropinomas, irrespective of Gsp mutations. Endocrine-Related Cancer 20 753-766. (doi:10.1530/ERC-12-0322)
Jane JA Jr 2008 Management of pediatric sellar tumors. Pediatric Endocrinology Reviews 5 (Suppl 2) 720-726.
Kasuki L, Vieira Neto L, Wildemberg LE, Colli LM, De Castro M, Takiya CM & Gadelha MR 2012 AIP expression in sporadic somatotropinomas is a predictor of the response to octreotide LAR therapy independent of SSTR2 expression. Endocrine-Related Cancer 19 L25-L29. (doi:10.1530/ERC-12-0020)
Lee JA, Carvalho CM & Lupski JR 2007 A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders. Cell 131 1235-1247. (doi:10.1016/j.cell.2007.11.037)
Lee M, Marinoni I, Irmler M, Psaras T, Honegger JB, Beschorner R, Anastasov N, Beckers J, Theodoropoulou M, Roncaroli F et al. 2013 Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecularmechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas. Acta Neuropathologica 126 137-150. (doi:10.1007/s00401-013-1132-7)
Lee M, Lupp A, Mendoza N, Martin NM, Beschorner R, Honegger J, Schlegel J, Shively T, Pulz E, Schulz S et al. 2014 SSTR3 is a putative target for the medical treatment of gonadotroph adenomas of the pituitary. Endocrine-Related Cancer 22 111-119. (doi:10.1530/ERC-14-0472)
Lloyd RV, Jin L, Chang A, Kulig E, Camper SA, Ross BD, Downs TR & Frohman LA 1992 Morphologic effects of hGRH gene expression on the pituitary, liver, and pancreas of MT-hGRH transgenic mice. An in situ hybridization analysis. American Journal of Pathology 141 895-906.
Magri F, Villa C, Locatelli D, Scagnelli P, Lagonigro MS, Morbini P, Castellano M, Gabellieri E, Rotondi M, Solcia E et al. 2010 Prevalence of double pituitary adenomas in a surgical series: clinical, histological and genetic features. Journal of Endocrinological Investigation 33 325-331. (doi:10.1007/BF03346594)
de Majo SF & Oñativia A 1960 Acromegaly and gigantism in a boy: comparison with 3 overgrown nonacromegalic children. Journal of Pediatrics 57 382-390. (doi:10.1016/S0022-3476(60)80246-6)
Mayo KE, Hammer RE, Swanson LW, Brinster RL, Rosenfeld MG & Evans RM 1988 Dramatic pituitary hyperplasia in transgenic mice expressing a human growth hormone-releasing factor gene. Molecular Endocrinology 2 606-612. (doi:10.1210/mend-2-7-606)
Moran A, Asa S, Kovacs K, Horvath E, Singer W, Sagman U, Reubi J, Wilson C, Larson R & Pescovits O 1990 Gigantism due to pituitary mammosomatotroph hyperplasia. New England Journal of Medicine 323 322-327. (doi:10.1056/NEJM199008023230507)
Mussig K, Gallwitz B, Honegger J, Strasburger CJ, Bidlingmaier M, Machicao F, Bornemann A, Ranke MB, Haring HU & Petersenn S 2007 Pegvisomant treatment in gigantism caused by a growth hormonesecreting giant pituitary adenoma. Experimental and Clinical Endocrinology & Diabetes 115 198-202. (doi:10.1055/s-2007-956172)
Rix M, Laurberg P, Hoejberg AS & Brock-Jacobsen B 2005 Pegvisomant therapy in pituitary gigantism: successful treatment in a 12-year-old girl. European Journal of Endocrinology/European Federation of Endocrine Societies 153 195-201. (doi:10.1530/eje.1.01956)
Salenave S, Boyce AM, Collins MT & Chanson P 2014 Acromegaly and McCune-Albright syndrome. Journal of Clinical Endocrinology and Metabolism 99 1955-1969. (doi:10.1210/jc.2013-3826)
Salpea P & Stratakis CA 2014 Carney complex and McCune-Albright syndrome: an overview of clinical manifestations and human molecular genetics. Molecular and Cellular Endocrinology 386 85-91. (doi:10.1016/j.mce.2013.08.022)
Spence HJ, Trias EP & Raiti S 1972 Acromegaly in a 9 and one-half-year-old boy. Pituitary function studies before and after surgery. American Journal of Diseases of Children 123 504-506. (doi:10.1001/archpedi.1972.02110110132018)
Stefaneanu L, Kovacs K, Horvath E, Asa SL, Losinski NE, Billestrup N, Price J & Vale W 1989 Adenohypophysial changes in mice transgenic for human growth hormone-releasing factor: a histological, immunocytochemical, and electron microscopic investigation. Endocrinology 125 2710-2718. (doi:10.1210/endo-125-5-2710)
Stratakis CA, Schussheim DH, Freedman SM, Keil MF, Pack SD, Agarwal SK, Skarulis MC, Weil RJ, Lubensky IA, Zhuang Z et al. 2000 Pituitary macroadenoma in a 5-year-old: an early expression of multiple endocrine neoplasia type 1. Journal of Clinical Endocrinology and Metabolism 85 4776-4780. (doi:10.1210/jcem.85.12.7064)
TheodoropoulouM, Tichomirowa MA, Sievers C, Yassouridis A, Arzberger T, Hougrand O, Deprez M, Daly AF, Petrossians P, Pagotto U et al. 2009 Tumor ZAC1 expression is associated with the response to somatostatin analog therapy in patients with acromegaly. International Journal of Cancer 125 2122-2126. (doi:10.1002/ijc.24602)
Todd RM 1958 Acromegaly in a girl of 8 years. Archives of Disease in Childhood 33 49-54. (doi:10.1136/adc.33.167.49)
Torronteras R, Gracia-Navarro F & Elsaesser F 1996 Different effects of somatostatin on in vitro growth hormone release in two porcine breeds with different growth rates. Journal of Neuroendocrinology 8 891-900. (doi:10.1111/j.1365-2826.1996.tb00817.x)
Torronteras R, Gracia-Navarro F & Elsaesser F 1997 Control of growth hormone secretion from porcine fetal and neonatal pituitary tissue in vitro by growth hormone-releasing hormone, somatostatin, and insulin-like growth factor. Neuroendocrinology 65 117-128. (doi:10.1159/000127171)
Torronteras R, Canalejo A & Elsaesser F 2012 Differential ontogenetic patterns of in vitro desensitization to GHRH in fetal and neonatal anterior pituitary. Neuroendocrinology 95 257-266. (doi:10.1159/000333779)
Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO, Schernthaner-Reiter MH, Szarek E, Leal LF, Caberg JH et al. 2014 Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. New England Journal of Medicine 371 2363-2374. (doi:10.1056/NEJMoa1408028)
Umemura S, Oda K, Utsunomiya H, Sanno N, Itoh J, Katakami H & Osamura RY 1995 Immunohistochemical characterization of "hyperplasia-adenoma sequence" in the pituitaries of transgenic mice expressing a human growth hormone-releasing factor gene. Tokai Journal of Experimental and Clinical Medicine 20 71-79.
Veldhuis JD, Iranmanesh A, Erickson E, Roelfsema F & Bowers CY 2012 Lifetime regulation of growth hormone (GH) secretion. In Handbook of Neuroendocrinology, pp 237-255. Eds G Fink, DW Pfaff & JW Levine. 1st New York, NY: Academic Press.
Villa C, Lagonigro MS, Magri F, Koziak M, Jaffrain-Rea ML, Brauner R, Bouligand J, Junier MP, Di Rocco F, Sainte-Rose C et al. 2011 Hyperplasia-adenoma sequence in pituitary tumorigenesis related to aryl hydrocarbon receptor interacting protein gene mutation. Endocrine-Related Cancer 18 347-356. (doi:10.1530/ERC-11-0059)
Zatelli MC, Maffei P, Piccin D, Martini C, Rea F, Rubello D, Margutti A, Culler MD, Sicolo N & degli Uberti EC 2005 Somatostatin analogs in vitro effects in a growth hormone-releasing hormone-secreting bronchial carcinoid. Journal of Clinical Endocrinology and Metabolism 90 2104-2109. (doi:10.1210/jc.2004-2156)
Zhang F, Khajavi M, Connolly AM, Towne CF, Batish SD & Lupski JR 2009 The DNA replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans. Nature Genetics 41 849-853. (doi:10.1038/ng.399)
Zimmerman D, Young WF Jr, Ebersold MJ, Scheithauer BW, Kovacs K, Horvath E, Whitaker MD, Eberhardt NL, Downs TR & Frohman LA 1993 Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation. Journal of Clinical Endocrinology and Metabolism 76 216-222. (doi:10.1210/jcem.76.1.8421089)