Reference : Poly(ethylene glycol) grafted polylactide based copolymers for the preparation of PLA...
Scientific journals : Article
Engineering, computing & technology : Materials science & engineering
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/181466
Poly(ethylene glycol) grafted polylactide based copolymers for the preparation of PLA-based nanocarriers and hybrid hydrogel
English
Riva, Raphaël [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Schmeits, Stéphanie [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Croisier, Florence [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Lecomte, Philippe mailto [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
Jérôme, Christine mailto [University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)]
2015
Clinical Hemorheology and Microcirculation
IOS Press
60
65-75
Yes (verified by ORBi)
International
1386-0291
Amsterdam
The Netherlands
[en] ring-opening polymerization (ROP)
[en] In previous works, poly(D,L-lactide-co-?CL-poly(ethylene glycol) (poly(D,L-La-co-?PEG?CL) amphiphilic graft- 10 copolymers were successfully synthesized according to a copper azide-alkyne cycloaddition (CuAAC) strategy. This paper aims 11 at reporting on the behavior of this amphiphilic copolymer in water, which was not studied in the previous paper. Moreover, 12 the ability of the copolymer to stabilize a PLA nanoparticles aqueous suspension is presented. For this purpose, dynamic 13 light scattering (DLS) and transmission electron microscopy (TEM) are proposed to characterize the nanoparticles in solution. 14 Otherwise, the strategy developed for the synthesis of the amphiphilic copolymers was adapted and extended to the synthesis of 15 PLA-based degradable hydrogel, potentially applicable as drug-loaded degradable polymer implant.
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; The Walloon Region (GGO6) in the frame of the project EMBIOSE
Researchers
http://hdl.handle.net/2268/181466
10.3233/CH-151932

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