Reference : Cochlear supporting cell transdifferentiation and integration into hair cell layers b...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Life sciences : Biochemistry, biophysics & molecular biology
Human health sciences : Otolaryngology
Cochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2 signalling
Defourny, Jean mailto [Institut Pasteur (Paris) > > > >]
Mateo Sanchez, Susana mailto [Université de Liège > Département des sciences cliniques > Neurologie >]
Schoonaert, Lies mailto [Katholieke Universiteit Leuven - KUL > > > >]
Robberecht, Wim mailto [Katholieke Universiteit Leuven - KUL > > > >]
Davy, Alice mailto [Université Paul Sabatier - Toulouse 3 - UPS > > > >]
Nguyen, Laurent mailto [Université de Liège > > GIGA - Neurosciences >]
Malgrange, Brigitte mailto [Université de Liège > > GIGA - Neurosciences >]
Nature Communications
Nature Pub.lishing Group
Yes (verified by ORBi)
United Kingdom
[en] inner ear ; ephrin
[en] In mammals, cochlear sensory hair cells that are responsible for hearing are postmitotic and are not replaced after loss. One of the most promising strategies to regenerate hair cells is to identify and inhibit the factors preventing the conversion of adjacent non-sensory supporting cells into hair cells. Here we demonstrate that mammalian hair cells can be directly generated from supporting cells by inhibition of ephrin-B2 signalling. Using either ephrin-B2 conditional knockout mice, shRNA-mediated gene silencing or soluble inhibitors, we found that downregulation of ephrin-B2 signalling at embryonic stages results in supporting cell translocation into hair cell layers and subsequent switch in cell identity from supporting cell to hair cell fate. As transdifferentiation is here a result of displacement across boundary, this original finding presents the interest that newly generated hair cells directly integrate either hair cell layer, then would be likely more rapidly able to fit into functional circuitry.

File(s) associated to this reference

Fulltext file(s):

Restricted access
Defourny - ncomms 2015.pdfPublisher postprint2.21 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.