[en] AIM: To evaluate the prognostic value of pretreatment FDG positron emission tomography computed tomography (PET-CT) in patients with hepatocarcinoma treated by liver transplantation (LT). METHODS: The authors retrospectively analyzed the data of 27 patients (mean age 58 +/- 9 years) who underwent FDG PET-CT before LT for hepatocarcinoma. Mean follow-up was 26 +/- 18 mo. The FDG PET/CT was performed according to a standard clinical protocol: 4 MBqFDG/kg body weight, uptake 60 min, low-dose non-enhanced CT. The authors measured the SUVmax and SUVmean of the tumor and the normal liver. The tumor/liver activity ratios (RSUVmax and RSUVmean) were tested as prognostic factors and compared to the following conventional prognostic factors: MILAN, CLIP, OKUDA, TNM stage, alphafoetoprotein level, portal thrombosis, size of the largest nodule, tumor differentiation, microvascular invasion, underlying cirrhosis and liver function. RESULTS: Overall and recurrence free survivals were 80.7% and 67.4% at 3 years, and 70.6% and 67.4% at 5 years, respectively. According to a multivariate Cox model, only FDG PET/CT RSUVmax predicted recurrence free survival. Even though the MILAN criteria alone were not predictive, it is worth noting that none of the patients outside the MILAN criteria and with RSUVmax < 1.15 relapsed. CONCLUSION: FDG PET/CT with an RSUVmax cut-off value of 1.15 is a strong prognostic factor for recurrence and death in patients with HCC treated by LT in this retrospective series. Further prospective studies should test whether this metabolic index should be systematically included in the preoperative assessment.
Disciplines :
Gastroenterology & hepatology Surgery
Author, co-author :
Detry, Olivier ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Govaerts, Laurence
De Roover, Arnaud ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
VANDERMEULEN, Morgan ; Centre Hospitalier Universitaire de Liège - CHU > Frais communs chirurgie
MEURISSE, Nicolas ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Malenga
BLETARD, Noëlla ; Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
Mbendi, Charles
LAMPROYE, Anne ; Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Honoré, Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Chirurgicale abdominale
MEUNIER, Paul ; Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic
Delwaide, Jean ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Hustinx, Roland ; Université de Liège - ULiège > Département des sciences cliniques > Médecine nucléaire
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
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