Reference : Prognostic value of (18)F-FDG PET/CT in liver transplantation for hepatocarcinoma.
Scientific journals : Article
Human health sciences : Gastroenterology & hepatology
Human health sciences : Surgery
http://hdl.handle.net/2268/180664
Prognostic value of (18)F-FDG PET/CT in liver transplantation for hepatocarcinoma.
English
Detry, Olivier [Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques >]
Govaerts, Laurence [> >]
De Roover, Arnaud mailto [Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques >]
VANDERMEULEN, Morgan mailto [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs chirurgie >]
MEURISSE, Nicolas mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
Malenga []
BLETARD, Noëlla mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
Mbendi, Charles [> >]
LAMPROYE, Anne mailto [Centre Hospitalier Universitaire de Liège - CHU > > Gastro-Entérologie-Hépatologie >]
Honoré, Pierre mailto [Université de Liège - ULiège > Département des sciences cliniques > Chirurgicale abdominale >]
MEUNIER, Paul mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic >]
Delwaide, Jean mailto [Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques >]
Hustinx, Roland mailto [Université de Liège - ULiège > Département des sciences cliniques > Médecine nucléaire >]
14-Mar-2015
World Journal of Gastroenterology
21
10
3049-54
Yes (verified by ORBi)
International
1007-9327
2219-2840
United States
[en] Cancer ; Hepatocellular cancer ; Hepatoma ; Liver transplantation
[en] AIM: To evaluate the prognostic value of pretreatment FDG positron emission tomography computed tomography (PET-CT) in patients with hepatocarcinoma treated by liver transplantation (LT). METHODS: The authors retrospectively analyzed the data of 27 patients (mean age 58 +/- 9 years) who underwent FDG PET-CT before LT for hepatocarcinoma. Mean follow-up was 26 +/- 18 mo. The FDG PET/CT was performed according to a standard clinical protocol: 4 MBqFDG/kg body weight, uptake 60 min, low-dose non-enhanced CT. The authors measured the SUVmax and SUVmean of the tumor and the normal liver. The tumor/liver activity ratios (RSUVmax and RSUVmean) were tested as prognostic factors and compared to the following conventional prognostic factors: MILAN, CLIP, OKUDA, TNM stage, alphafoetoprotein level, portal thrombosis, size of the largest nodule, tumor differentiation, microvascular invasion, underlying cirrhosis and liver function. RESULTS: Overall and recurrence free survivals were 80.7% and 67.4% at 3 years, and 70.6% and 67.4% at 5 years, respectively. According to a multivariate Cox model, only FDG PET/CT RSUVmax predicted recurrence free survival. Even though the MILAN criteria alone were not predictive, it is worth noting that none of the patients outside the MILAN criteria and with RSUVmax < 1.15 relapsed. CONCLUSION: FDG PET/CT with an RSUVmax cut-off value of 1.15 is a strong prognostic factor for recurrence and death in patients with HCC treated by LT in this retrospective series. Further prospective studies should test whether this metabolic index should be systematically included in the preoperative assessment.
http://hdl.handle.net/2268/180664
10.3748/wjg.v21.i10.3049

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