Effects of transforming growth factor-beta 1 on human adrenocortical fasciculata-reticularis cell differentiated functions.

LEBRETHON, Marie-Christine; Jaillard, C.; Naville, D.; Begeot, M.; Saez, J. M.

doi:10.1210/jcem.79.4.7962271

Article (Scientific journals)

Effects of transforming growth factor-beta 1 on human adrenocortical fasciculata-reticularis cell differentiated functions.

LEBRETHON, Marie-Christine; Jaillard, C.; Naville, D. et al.

1994 • In Journal of Clinical Endocrinology and Metabolism, 79 (4), p. 1033-9

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https://hdl.handle.net/2268/180644

DOI
10.1210/jcem.79.4.7962271

PubMed
7962271

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Keywords :

Adrenal Cortex/cytology/drug effects/physiology; Adrenocorticotropic Hormone/genetics/pharmacology; Cell Differentiation; Cells, Cultured; Dehydroepiandrosterone/analogs & derivatives/biosynthesis; Dehydroepiandrosterone Sulfate; Enzymes/genetics; Humans; Hydrocortisone/biosynthesis; RNA, Messenger/metabolism; Receptors, Angiotensin/metabolism; Receptors, Transforming Growth Factor beta/metabolism; Steroids/biosynthesis; Transforming Growth Factor beta/genetics/pharmacology

Abstract :

[en] Transforming growth factor-beta 1 (TGF beta 1) has been reported to have a strong inhibitory effect on the specific function of adrenal cells of several species. In the present study, we examined the effects of TGF beta 1 on cultured human fasciculata-reticularis cells. TGF beta 1 alone had no effect on ACTH receptor messenger ribonucleic acid (mRNA) levels and was unable to reduce the strong stimulatory effects of ACTH on its own receptor. However, TGF beta 1 enhanced angiotensin-II type 1 receptor mRNA and binding sites. Treatment with TGF beta 1 increased significantly the levels of 3 beta-hydroxysteroid dehydrogenase mRNA, reduced those of cytochrome P-450 17 alpha-hydroxylase mRNA, and had no effect on cholesterol side-chain cleavage cytochrome P-450 mRNA. Whatever the experimental condition, TGF beta 1 did not reduce basal or ACTH-stimulated cortisol production, but the production of dehydroepiandrosterone sulfate of TGF beta 1-treated cells was always decreased. The effects of TGF beta 1 on 3 beta-hydroxysteroid dehydrogenase mRNA and dehydroepiandrosterone sulfate were opposite the change observed at the time of adrenarche. As adrenal cells express TGF beta 1 mRNA, it is tempting to postulate that a local diminution of TGF beta 1 might be involved in adrenarche. Our findings also illustrate the specific species differences and, therefore, the caution to extrapolate to humans the results observed in other species.

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

LEBRETHON, Marie-Christine ; Centre Hospitalier Universitaire de Liège - CHU > Pédiatrie

Jaillard, C.

Naville, D.

Begeot, M.

Saez, J. M.

Language :

English

Title :

Effects of transforming growth factor-beta 1 on human adrenocortical fasciculata-reticularis cell differentiated functions.

Publication date :

1994

Journal title :

Journal of Clinical Endocrinology and Metabolism

ISSN :

0021-972X

eISSN :

1945-7197

Publisher :

Oxford University Press, New York, United States - New York

Volume :

Issue :

Pages :

1033-9

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 16 April 2015

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Bibliography

Lyons RM, Moses HL. 1990 Transforming growth factors and the regulation of cell proliferation. Eur J Biochem. 187:467-473.
Massague J. 1990 The transforming growth factor-β family. Annu Rev Cell Biol. 6:597-641.
Roberts AB, Sporn MB. 1990 The transforming growth factors-β. In: Spom MB, Roberts AB, eds. Handbook of experimental pharmacology. New York: Springer-Verlag; vol 95/1:419-472.
Burt DW, Paton IR. 1992 Evolutionary origins of the transforming growth facor-d gene family. DNA Cell Biol. 11:497-510.
Wang XF, Lin HY, Ng-Eaton E, Downward J, Lodish HF, Weinberg RA. 1991 Expression cloning and characterization of the TGβ type III receptor. Cell. 67:797-805.
Lopez-Casillas F, Cheifetz S, Doody J, Andres JL, Lane WS, Massague J. 1991 Structure, expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system. Cell. 67:785-795.
Lin HY, Wang XF, Ng-Eaton E, Weinberg RA, Lodish HF. 1992 Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell. 68:775-785.
Ebner R, Chen RH, Shun L, et al. 1993 Cloning of a type I TGF-β receptor and its effects on TGF-β binding to the type II receptor. Sciences. 260:1344-1348.
Lopez-Casillas F, Wrana JL, Massague J. 1993 Betaglycan presents ligand to the TGFβ signaling receptor. Cell. 73:1435-1444.
Wrana JL, Attisano L, Carcamo J, et al. 1992 TGF-β signals through a heteromeric protein kinase receptor complex. Cell. 71:1003-1014.
Chen RH, Ebner R, Derinck R. 1993 Inactivation of the type II receptor reveals two receptors pathways for the diverse TGF-β activities. Science. 260:1335-1338.
Ying SY, Becker A, Baird A, et al. 1986 Type beta transforming growth factor (TGF-β) is a potent stimulator of the basal secretion of follicle stimulating hormone (FSH) in a pituitary monolayer system. Biochem Biophys Res Commun. 135:950-956.
Knecht M, Feng F, Catt KJ. 1986 Transforming growth factor-beta regulates the expresion of luteinzing hormone receptors in ovarian granulosa cells. Biochem Biophys Res Commun. 139:800-807.
Ying SY, Becker A, Ling N, Ueno N, Guillemen R. 1986 Inhibin and beta transforming growth factor (TGFβ) have opposite modulating effects on the follicle stimulating hormone (FSH)-induced aromatase activity on cultured rat granulosa cells. Biochem Biophys Res Commun. 136:969-975.
Adashi EY, Resnick CE. 1986 Antagonistic interactions of transforming growth factors in the regulation of granulosa cell differentiation. Endocrinology. 119:1879-1881.
Lin T, Blaisdell J, Haskell JF. 1987 Transforming growth factor-β inhibits Leydig cell steroidogenesis in primary culture. Biochem Biophys Res Commun. 146:387-394.
Avallet O, Vigier M, Perrard-Sapori MH, Saez JM. 1987 Transforming growth factor 0 inhibits leydig cell functions. Biochem Biophys Res Commun. 146:575-581.
Hotta M, Baird A. 1986 Differential effects of transforming growth factor type β on the growth, function of adrenocortical cells, in vitro. Proc Natl Acad Sd USA. 83:7795-7799.
Rainey WE, Viard I, Mason JI, Cochet C, Chambaz EM, Saez JM. 1988 Effects of transforming growth factor beta on ovine adrenocortical cells. Mol Cell Endocrinol. 60:189-198.
Rainey WE, Naville D, Saez JM, et al. 1990 Transforming growth factor-β inhibits steroid 17α-hydroxylase cytochrome P-450 expression in ovine adrenocortical cells. Endocrinology. 127:1910-1915.
Feige JJ, Cochet C, Rainey WE, Madani C, Chambaz EM. 1987 Type β transforming growth factor effects adrenocortical cell-differentiated functions. J Biol Chem. 262:13491-13495.
Perrin A, Pascal O, Defaye G, Feige JJ, Chambaz EM. 1990 Transforming growth factor β1 is a negative regulator of steroid 17α-hydroxylase expression in bovine adrenocortical cells. Endocrinology. 128:357-362.
Rainey WE, Oka K, Magness RR, Mason JI. 1991 Ovine fetal adrenal synthesis of cortisol: regulation by adrenocorticotropin, angiotensin II, and transforming growth factor β. Endocrinology. 129:1784-1790.
Rainey WE, Naville D, Mason JI. 1991 Regulation of 3β -hydroxy-steroid dehydrogenase in adrenocortical cells: effects of angiotensin II and transforming growth factor beta. Endocr Res. 17:281-296.
Naville D, Rainey WE, Mason JI. 1991 Corticotropin regulation of 3β-hydroxysteroid dehydrogenase/A5-4-isomerase in ovine adrenocortical cells: inhibition by transforming growth factor β. Mol Cell Endocrinol. 75:257-263.
Rainey WE, Viard I, Saez JM. 1989 Transforming growth factor β treatment decreases ACTH receptors on ovine adrenocortical cells. J Biol Chem. 264:21474-21477.
Feige JJ, Cochet C, Savona C, et al. 1991 Transforming growth factor β1: an autocrine regulator of adrenocortical steroidogenesis. Endocr Res. 17:267-279.
Cochet C, Feige JJ, Chambaz EM. 1988 Bovine adrenocortical cells exhibit high affinity transforming growth factor-β receptors which are regulated by adrenocorticotropin. J Biol Chem. 263:5707-5713.
Keramidas M, Bourgarit JJ, Tabone E, Corticelli P, Chambaz EM, Feige JJ. 1991 Immunolocalization of transforming growth factor-β1 in the bovine adrenal cortex using antipeptide antibodies. Endocrinology. 129:517-526.
Parker LN. 1991 Adrenarche. Endocrinol Metab Clin North Am. 20:71-78.
Migeon CJ, Keller AR, Laurence B, Shepard THI. 1957 Dehydro-epiandrosterone and androsterone levels in human plasma. Effect of age and sex; day-to-day and diurnal variations. J Clin Endocrinol Metab. 17:1051-1056.
Luuthe V, Lachance Y, Labrie C, et al. 1989 Full length cDNA structure and deduced amino acid sequence of human 3β-hydroxy-5-ene steroid dehydrogenase. Mol Endocrinol. 3:1310-1312.
John ME, John MC, Ashley P, MacDonald RJ, Simpson ER, Waterman MR. 1984 Identification and characterization of cDNA clones specific for cholesterol side-chain cleavage cytochrome P-450. Proc Natl Acad Sci USA. 81:5628-5632.
Zubert MX, John ME, Okamura T, Simpson ER, Waterman MR. 1986 Bovine adrenocortical cytochrome P-45017α: regulation of gene expression and elucidation of primary sequence. J Biol Chem. 261:2475-2482.
Naville D, Lebrethon MC, Kermabon AY, Rouer E, Benarous R, Saez JM. 1993 Characterization and regulation of angiotensin II type 1 receptor (binding and mRNA) in human adrenal fasciculata-reticularis cells. FEBS Lett. 321:184-188.
Mountjoy KG, Robbins LS, Mortrud MT, Cone RD. 1992 The cloning of a family of genes that encode the melanocortin receptors. Science. 257:1248-1251.
Ouali R, Poulette S, Penhoat A, Saez JM. 1992 Characterization and coupling of angiotensin II receptor subtypes in cultured bovine adrenal fasciculata cells. J Steroid Biochem Biol. 43:271-280.
Penhoat A, Jaillard C, Crozat A, Saez JM. 1988 Regulation of angiotensin-II receptors and steroidogenic responsiveness in cultured bovine fasciculata and glomerulosa adrenal cells. Eur J Biochem. 172:247-254.
Raeside JI, Renaud RL. 1983 Estrogen and androgen production by purified Leydig cells of mature boars. Biol Reprod. 28:727-733.
Frolik CA, Wakefield LM, Smith DM, Sporn MB. 1984 Characterization of a membrane receptor for transforming growth factor-β in normal rat kidney fibroblasts. J Biol Chem. 259:10995-11000.
Pilch F, Czech M. 1980 The subunit structure of the high affinity insulin receptor. J Biol Chem. 255:1722-1731.
Chomczynski P, Sacchi N. 1987 Single step method of RNA isolation by acid guanidium thiocyanate phenol chloroform extraction. Anal Biochem. 162:156-159.
Barbu V, Dautry F. 1989 Nothem blot normalization with 28S rRNA ologonucleotide probe. Nucleic Acids Res. 17:7115-7117.
Boyd FT, Massague J. 1989 Transforming growth factor-B inhibition of epithelial cell proliferayion linked to the expression of a 53-kD membrane receptor. J Biol Chem. 264:2272-2278.
Lebrethon MC, Naville D, Begeot M Saez JM. 1994 Regulation of corticotropin receptor number and mRNA in cultured human adrenocortical cells by corticotropin and angiotensin-II. J Clin Invest. 93:1828-1833.
Penhoat A, Jaillard C, Saez JM. 1994 Regulation of bovine adrenal cell corticotropin receptor mRNA levels by corticotropin (ACTH) and angiotensin-II (A-II). Mol Cell Endocrinol. 103:R7-R10.
Naseeruddin SA, Hornsby PJ. 1990 Regulation of lid- and 17a-hydroxylases in cultured bovine adrenocortical cells: 3'-5'-cyclic adenosine monophosphate, insulin-like growth factor-I, and activators of protein kinase C. Endocrinology. 127:1673-1681.
Lebrethon MC, Jaillard C, Defayes G, Begeot M, Saez JM. 1994 Human cultured adrenal fasciculata-reticularis cells are targets for angiotensin II: effects on P450scc (cholesterol side-chain cleavage), P45017α (17α-hydroxylase), 3 β-hydroxy steroid dehydrogenase mRNA and proteins and on steroidogenic responsiveness to corticotropin and angiotensin II. J Clin Endocrinol Metab. 78:1212-1219.
Rich BH, Rosenfield RL, Lucky AW, Helke JC, Otto P. 1981 Adrenarche: changing adrenal response to adrenocorticotropin. J Clin Endocrinol Metab. 52:1129-1136.