Natural antibody--complement dependent neutralization of bovine herpesvirus 4 by human serum

[en] In contrast to most gammaherpesviruses, Bovine herpesvirus 4 (BoHV-4) has a broad range of host species both in vitro and in vivo. Several in vitro studies demonstrated that some human cell lines are sensitive or even permissive to BoHV-4. These observations led to the hypothesis that cross-species transmission of BoHV-4 could lead to human infections. In the present study, we investigate the sensitivity of BoHV-4 to neutralization by naïve human sera in order to determine if humans exhibit innate anti-viral activities against this virus. Our results demonstrate that human sera from naïve individuals, in contrast to the sera of naïve subjects from various animal species, neutralize BoHV-4 efficiently. A series of complementary experiments were performed to unravel the mechanism(s) of this neutralization. The data obtained in this study demonstrates that human serum neutralizes BoHV-4 in a complement dependent manner activated by natural antibodies raised against the Galalpha1-3Galbeta1-4GlcNAc-R epitope expressed by bovine cells

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Machiels, Bénédicte ; Université de Liège - ULiège > Immunologie et vaccinologie

Gillet, Laurent ; Université de Liège - ULiège > Immunologie et vaccinologie

Brito, Sieberth Do Nascimento

Drion, Pierre ; Université de Liège - ULiège > Services généraux (Faculté de médecine vétérinaire) > Méth. expér. des anim. de labo et éthique en expér. animale

Delforge, Cédric ; Université de Liège - ULiège > Immunologie et vaccinologie

Nizet, Yannick; Université Catholique de Louvain - UCL

Gianello, Pierre; Université Catholique de Louvain - UCL

Bona, Christophe

Costes, Bérénice ; Université de Liège - ULiège > Immunologie et vaccinologie

Markine-Goriaynoff, Nicolas

Vanderplasschen, Alain ; Université de Liège - ULiège > Immunologie et vaccinologie

Language :

English

Title :

Natural antibody--complement dependent neutralization of bovine herpesvirus 4 by human serum

Publication date :

2007

Journal title :

Microbes and Infection

ISSN :

1286-4579

Publisher :

Elsevier Science, Amsterdam, Netherlands

Volume :

Issue :

14-15

Pages :

1530-1537

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VPN-4PJCYK0-2&_user=532038&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000026659&_version=1&_urlVersion=0&_userid=532038&md5=1f7db6185dc6f13484b1d3019ea5ad3e

Available on ORBi :

since 17 November 2010

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