[en] Streptococcus agalactiae (Group B Streptococcus, GBS) is a commensal of the digestive and genitourinary tracts of humans that emerged as the leading cause of bacterial neonatal infections in Europe and North America during the 1960s. Due to the lack of epidemiological and genomic data, the reasons for this emergence are unknown. Here we show by com- parative genome analysis and phylogenetic reconstruction of 229 isolates that the rise of human GBS infections corresponds to the selection and worldwide dissemination of only a few clones. The parallel expansion of the clones is preceded by the insertion of integrative and conjugative elements conferring tetracycline resistance (TcR). Thus, we propose that the use of tetracycline from 1948 onwards led in humans to the complete replacement of a diverse GBS population by only few TcR clones particularly well adapted to their host, causing the observed emergence of GBS diseases in neonates.
Research Center/Unit :
Institut Pasteur Genopole France
Disciplines :
Microbiology
Author, co-author :
Da Cunha, Violette; Institut Pasteur France > Unité de Biologie des Bacteries Pathogènes à Gram-positif
Davies, MR; he Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 15A, UK
Douarre, Pierre-Emmanuel; Institut Pasteur France > Unité de Biologie des Bacteries Pathogènes à Gram-positif
MELIN, Pierrette ; Centre Hospitalier Universitaire de Liège - CHU > Microbiologie médicale
Glaser, Philippe; Institut Pasteur France
Language :
English
Title :
Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline
Publication date :
04 August 2014
Journal title :
Nature Communications
eISSN :
2041-1723
Publisher :
Nature Pub.lishing Group, London, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
FP7 - 200481 - DEVANI - Design of a vaccine to immunize neonates against GBS infections through a durable maternal immune response
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