Associations of Plasma Concentrations of Dichlorodiphenyldichloroethylene and Polychlorinated Biphenyls with Prostate Cancer: A Case–Control Study in Guadeloupe (French West Indies)
Endocrine Disrupting Chemicals; Prostate Cancer; PCB; DDE; French West Indies; Guadeloupe
Abstract :
[en] Background: Long-term exposure to persistent pollutants with hormonal properties (endocrine-disrupting chemicals, EDCs) may contribute to the risk of prostate cancer (PCa). However, epidemiological evidence remains limited.
Objectives: We investigated the relationship between PCa and plasma concentrations of universally widespread pollutants, in particular p,p’-
dichlorodiphenyl dichloroethene (DDE) and the non-dioxin like polychlorinated biphenyl congener 153 (PCB153).
Methods and Findings: We evaluated before treatment 576 men with newly diagnosed PCa and 655 controls in Guadeloupe (French West Indies). Exposure was analyzed according to case-control status. Associations were assessed by unconditional logistic regression analysis, controlling for confounding factors. Missing data were handled by multiple imputation. We
estimated a significant positive association between DDE and PCa (adjusted odds ratio [OR] 1.53; 95% CI 1.02, 2.30 for the highest versus lowest quintile of exposure; PTrend= 0.01). PCB153 was inversely associated with PCa (OR 0.30; 95% CI 0.19, 0.47 for the highest versus lowest quintile of exposure values; PTrend<0.001). Also, PCB153 was more strongly associated to low-grade than high grade PCa.
Conclusions: Associations of PCa with DDE and PCB153 were in opposite directions. This may reflect differences in the mechanisms of action of these EDCs, and although our findings need to be replicated in other populations, they are consistent with complex effects of EDCs on human health.
Disciplines :
Oncology
Author, co-author :
Emeville, Elise; Institut National de la Santé et de la Recherche Médicale - INSERM > UMR 1085 > IRSET
Giusti, Arnaud ; Université de Liège - ULiège > Département de Biologie, Ecologie et Evolution > Département de Biologie, Ecologie et Evolution
Coumoul, Xavier; Institut National de la Santé et de la Recherche Médicale - INSERM > UMR-S 747 > Toxicologie Pharmacologie et Signalisation Cellulaire
Thomé, Jean-Pierre ; Université de Liège - ULiège > Département de Biologie, Ecologie et Evolution > Ecologie animale et écotoxicologie
Blanchet, Pascal; Centre Hospitalier Universitaire Guadeloupe > Service d'Urologie
Multigner, Luc; Institut National de la Santé et de la Recherche Médicale - INSERM > UMR 1085 > IRSET
Language :
English
Title :
Associations of Plasma Concentrations of Dichlorodiphenyldichloroethylene and Polychlorinated Biphenyls with Prostate Cancer: A Case–Control Study in Guadeloupe (French West Indies)
Publication date :
April 2015
Journal title :
Environmental Health Perspectives
ISSN :
0091-6765
Publisher :
US Dept Health Human Sciences Public Health Science, Research Triangle Park, Pakistan
Volume :
123
Issue :
4
Pages :
317-323
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
French National Health Directorate LNCC - Ligue Nationale Contre le Cancer [FR]
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