Article (Scientific journals)
Phenotypes de la broncho-pneumopathie chronique obstructive.
Corhay, Jean-Louis; SCHLEICH, FLorence; Louis, Renaud
2014In Revue Médicale de Liège, 69 (7-8), p. 415-21
Peer reviewed
 

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Keywords :
Genetic Predisposition to Disease; Humans; Phenotype; Pulmonary Disease, Chronic Obstructive/classification/diagnosis/genetics/therapy
Abstract :
[en] Chronic Obstructive Pulmonary Disease (COPD) is a multi-dimensional disorder with multiple phenotypes. The GOLD guidelines, used for the diagnosis, staging and treatment of COPD, do not fully reflect the heterogeneous nature of the disease. Historically, the two most recognized clinical phenotypes of COPD are emphysema and chronic bronchitis. Most COPD patients encountered in practice actually share, both of these features. Genetic background, clinical presentation, variation in the response to treatment and propensity to exacerbations may also identify other phenotypes. Recently, using a mathematical approach, such as cluster analysis, which is based on pre-selected parameters, other interesting phenotypes were identified. A precise definition of COPD phenotypes should lead to a more targeted therapeutic approach based on these phenotypes. The purpose of this article is to point out that COPD is a heterogeneous disease and to summarize the current data available about the phenotypes of this disease.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Corhay, Jean-Louis ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
SCHLEICH, FLorence ;  Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
Louis, Renaud ;  Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Language :
French
Title :
Phenotypes de la broncho-pneumopathie chronique obstructive.
Alternative titles :
[en] Phenotypes in chronic obstructive pulmonary disease
Publication date :
July 2014
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
69
Issue :
7-8
Pages :
415-21
Peer reviewed :
Peer reviewed
Available on ORBi :
since 16 February 2015

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