Reference : Chronic Cutaneous Hyalophomycosis by Paecilomyces
Scientific journals : Article
Human health sciences : Dermatology
Chronic Cutaneous Hyalophomycosis by Paecilomyces
BOUFFLETTE, Nicolas mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatologie >]
Arrese Estrada, Jorge mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
LEONARD, Philippe mailto [Centre Hospitalier Universitaire de Liège - CHU > > Maladies infectieuses et médecine interne générale >]
NIKKELS, Arjen mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatologie >]
Open Dermatology Journal
[en] Hyalohyphomycosis ; immunosuppression ; paecilomyceslilacinus ; voriconazole ; skin infection
[en] Paecilomyces lilacinus is a ubiquitous saprophytic fungus that rarely causes infections in humans, frequently affecting the eyes and the skin. Cutaneous and subcutaneous infections mainly occur in immunocompromised hosts but have occasionally been reported in immunocompetent patients. The clinical spectrum is highly heterogeneous and diagnosis is often delayed.
A 60-year-old woman with idiopathic chronic necrotizing vasculitis treated since 10 years with a series of immunosuppressive therapies presented since three years various clinical presentations of chronic hyalohyphomycosis caused by P. lilacinus. Diagnosis was only obtained three years after the first clinical signs, following the histologic analysis of the surgical excision of a cutaneous abscess. Treatment with oral voriconazole was successful.
This case report illustrates the highly heterogeneous clinical aspects of hyalohyphomycosis by P. lilacinus leading to a delay in diagnosis and treatment, particularly in the immunosuppressed patient.

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