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Doctoral thesis (Dissertations and theses)
Supercritical Carbon Dioxide Assisted Impregnation to Prepare Drug-eluting Polymer Implants
Champeau, Mathilde
2014
 

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Keywords :
Supercritical CO2; impregnation; implant
Abstract :
[en] The scCO2 impregnation process is a promising alternative to other manufacturing process to prepare drug-eluting polymer implants. This work enabled to rationalize the influence of the key parameters governing this process and to determine in which extent this process can be used to prepare drug-eluting implants. We have combined the information obtained with traditional polymer characterization techniques and a newly characterization set-up we have developed that is based on in situ FTIR micro-spectroscopy. We have worked on the impregnation of sutures made of PLLA, PP and PET with two anti-inflammatory drugs namely ketoprofen and aspirin. Firstly, the thermodynamic behaviors of the systems drug/CO2 (solubility and speciation of the drug) and polymer/CO2 (CO2 sorption, polymer swelling, evolution of the polymer microstructure and of the tensile properties) were studied as a function of pressure and temperature. Then, the scCO2 impregnation process was investigated. The impact of the operational conditions on the drug loading (contact time, pressure, temperature and depressurization conditions) was explored and accounted regarding to the CO2 sorption, the swelling, the drug solubility as well as the changes in the polymer microstructure with the experimental conditions and the presence of the drug. The drug/polymer affinity was also explored. The tensile properties of the impregnated fibers were also evaluated. PLLA was more impregnated (up to 32%) than PP and PET (up to 5%) in the investigated conditions. Finally, we have shown that the drug release can be tuned from 3 days to 3 months by varying the impregnation and depressurization conditions on the system PLLA/Ketoprofen.
Disciplines :
Chemistry
Author, co-author :
Champeau, Mathilde ;  Université de Liège - ULiège > Form. doct. sc. (chimie - Bologne)
Language :
English
Title :
Supercritical Carbon Dioxide Assisted Impregnation to Prepare Drug-eluting Polymer Implants
Defense date :
04 November 2014
Number of pages :
229
Institution :
ULiège - Université de Liège
Université de Bordeaux
Degree :
Diplôme de doctorat
Promotor :
Jérôme, Christine  ;  Université de Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM)
Tassaing, Thierry
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since 13 November 2014

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