Dephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients.

DELANAYE, Pierre; KRZESINSKI, Jean-Marie; Warling, X; Moonen, Martial; Smelten, Nicole; Médart; Pottel, H; CAVALIER, Etienne

doi:10.1186/1471-2369-15-145

Article (Scientific journals)

Dephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients.

DELANAYE, Pierre; KRZESINSKI, Jean-Marie; Warling, X et al.

2014 • In BMC Nephrology, 15, p. 145

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/173365

DOI
10.1186/1471-2369-15-145

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25190488

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Abstract :

[en] Background: Matrix Gla protein (MGP) is known to act as a potent local inhibitor of vascular calcifications. However, in order to be active, MGP must be phosphorylated and carboxylated, with this last process being dependent on vitamin K. The present study focused on the inactive form of MGP (dephosphorylated and uncarboxylated: dp-ucMGP) in a population of hemodialyzed (HD) patients. Results found in subjects being treated or not with vitamin K antagonist (VKA) were compared and the relationship between dp-ucMGP levels and the vascular calcification score were assessed. Methods: One hundred sixty prevalent HD patients were enrolled into this observational cohort study, including 23 who were receiving VKA treatment. The calcification score was determined (using the Kauppila method) and dp-ucMGP levels were measured using the automated iSYS method. Results: dp-ucMGP levels were much higher in patients being treated with VKA and little overlap was found with those not being treated (5604 [3758; 7836] vs. 1939 [1419; 2841] pmol/L, p <0.0001). In multivariate analysis, treatment with VKA was the most important variable explaining variation in dp-ucMGP levels even when adjusting for all other significant variables. In the 137 untreated patients, dp-ucMGP levels were significantly (p < 0.05) associated both in the uni- and multivariate analysis with age, body mass index, plasma levels of albumin, C-reactive protein, and FGF-23, and the vascular calcification score. Conclusion: We confirmed that the concentration of dp-ucMGP was higher in HD patients being treated with VKA. We observed a significant correlation between dp-ucMGP concentration and the calcification score. Our data support the theoretical role of MGP in the development of vascular calcifications. We confirmed the potential role of the inactive form of MGP in assessing the vitamin K status of the HD patients.

Disciplines :

Laboratory medicine & medical technology

Author, co-author :

DELANAYE, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Néphrologie

KRZESINSKI, Jean-Marie ; Centre Hospitalier Universitaire de Liège - CHU > Néphrologie

Warling, X

Moonen, Martial

Smelten, Nicole ; Université de Liège - ULiège > Département des sciences cliniques > Néphrologie

Médart

Pottel, H

CAVALIER, Etienne ; Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale

Language :

English

Title :

Dephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients.

Publication date :

September 2014

Journal title :

BMC Nephrology

eISSN :

1471-2369

Publisher :

BioMed Central

Volume :

Pages :

145

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 24 October 2014

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