Article (Scientific journals)
Effects of cholecalciferol supplementation and optimized calcium intakes on vitamin D status, muscle strength and bone health: A one-year pilot randomized controlled trial in adults with severe burns
ROUSSEAU, Anne-Françoise; FOIDART-DESSALLE, Marguerite; LEDOUX, Didier et al.
2015In Burns: Journal of the International Society for Burn Injuries, 41 (2), p. 317-325
Peer Reviewed verified by ORBi
 

Files


Full Text
effects of cholecalciferol burns.pdf
Publisher postprint (1.04 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
burn injury; vitamin D; muscle strength; Isokinetic dynamometry; Bone mineral density
Abstract :
[en] Objective: Burn patients are at risk of hypovitaminosis D and osteopenia or sarcopenia. Vitamin D pleiotropic effects may influence bone and muscle health. The aim of this pilot study was to assess effects of a cholecalciferol (VD3) supplementation and an optimized calcium (Ca) regimen on vitamin D (VD) status, bone and muscle health during sequelar stage of burn injury. Design: Monocentric randomized controlled trial. Methods: Fifteen adults with thermal burns dating from 2 to 5 years were randomized into two groups. For 12 months, they either received a quarterly IM injection of 200,000 IU VD3 and daily oral Ca (Group D) or placebo (Group P). VD status and bone remodeling markers were assessed every 3 months. Knee muscle strength and bone mineral density were, respectively, assessed using isokinetic dynamometry and dual X-ray absorptiometry at initiation (M0) and completion (M12) of the protocol. Results: Of all the patients, 66% presented with VD deficiency and 53% (with 3 men <40 y) were considered osteopenic at inclusion. After one year, calcidiol levels significantly increased in Group D to reach 40 (37–61) ng/ml. No significant change in bone health was observed in both groups while Group D significantly improved quadriceps strength when tested at high velocity. Conclusions: This VD3 supplementation was safe and efficient to correct hypovitaminosis D in burn adults. When combined with optimized Ca intakes, it demonstrated positive effects on muscle health but not on bone health. A high prevalence of hypovitaminosis D and osteopenia in these patients, as well as their wide range of muscle performances, seem to be worrying when considering rehabilitation and quality of life.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
ROUSSEAU, Anne-Françoise  ;  Centre Hospitalier Universitaire de Liège - CHU > Soins intensifs
FOIDART-DESSALLE, Marguerite ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur
LEDOUX, Didier  ;  Centre Hospitalier Universitaire de Liège - CHU > Soins intensifs
REMY, Christophe ;  Centre Hospitalier Universitaire de Liège - CHU > HOSPITALISATION - CENTRE DES BRULES (SI +2C)
CROISIER, Jean-Louis ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur
DAMAS, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Soins intensifs
CAVALIER, Etienne  ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Language :
English
Title :
Effects of cholecalciferol supplementation and optimized calcium intakes on vitamin D status, muscle strength and bone health: A one-year pilot randomized controlled trial in adults with severe burns
Publication date :
March 2015
Journal title :
Burns: Journal of the International Society for Burn Injuries
ISSN :
0305-4179
eISSN :
1879-1409
Publisher :
Elsevier, New York, United States - New York
Volume :
41
Issue :
2
Pages :
317-325
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 October 2014

Statistics


Number of views
101 (18 by ULiège)
Number of downloads
6 (6 by ULiège)

Scopus citations®
 
40
Scopus citations®
without self-citations
36
OpenCitations
 
34

Bibliography


Similar publications



Contact ORBi