Effects of cholecalciferol supplementation and optimized calcium intakes on vitamin D status, muscle strength and bone health: A one-year pilot randomized controlled trial in adults with severe burns
burn injury; vitamin D; muscle strength; Isokinetic dynamometry; Bone mineral density
Abstract :
[en] Objective: Burn patients are at risk of hypovitaminosis D and osteopenia or sarcopenia.
Vitamin D pleiotropic effects may influence bone and muscle health. The aim of this pilot
study was to assess effects of a cholecalciferol (VD3) supplementation and an optimized
calcium (Ca) regimen on vitamin D (VD) status, bone and muscle health during sequelar
stage of burn injury.
Design: Monocentric randomized controlled trial.
Methods: Fifteen adults with thermal burns dating from 2 to 5 years were randomized into
two groups. For 12 months, they either received a quarterly IM injection of 200,000 IU VD3
and daily oral Ca (Group D) or placebo (Group P). VD status and bone remodeling markers
were assessed every 3 months. Knee muscle strength and bone mineral density were,
respectively, assessed using isokinetic dynamometry and dual X-ray absorptiometry at
initiation (M0) and completion (M12) of the protocol.
Results: Of all the patients, 66% presented with VD deficiency and 53% (with 3 men <40 y)
were considered osteopenic at inclusion. After one year, calcidiol levels significantly
increased in Group D to reach 40 (37–61) ng/ml. No significant change in bone health was
observed in both groups while Group D significantly improved quadriceps strength when
tested at high velocity.
Conclusions: This VD3 supplementation was safe and efficient to correct hypovitaminosis D
in burn adults. When combined with optimized Ca intakes, it demonstrated positive effects
on muscle health but not on bone health. A high prevalence of hypovitaminosis D and
osteopenia in these patients, as well as their wide range of muscle performances, seem to be
worrying when considering rehabilitation and quality of life.
LEDOUX, Didier ; Centre Hospitalier Universitaire de Liège - CHU > Soins intensifs
REMY, Christophe ; Centre Hospitalier Universitaire de Liège - CHU > HOSPITALISATION - CENTRE DES BRULES (SI +2C)
CROISIER, Jean-Louis ; Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur
DAMAS, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Soins intensifs
CAVALIER, Etienne ; Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Language :
English
Title :
Effects of cholecalciferol supplementation and optimized calcium intakes on vitamin D status, muscle strength and bone health: A one-year pilot randomized controlled trial in adults with severe burns
Publication date :
March 2015
Journal title :
Burns: Journal of the International Society for Burn Injuries
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