[en] A new family of lipopeptides produced by Bacillus thuringiensis, the kurstakins, was discovered in 2000 and considered as a biomarker of this species. Kurstakins are lipoheptapeptides displaying antifungal activities against Stachybotrys charatum. Recently, the biosynthesis mechanism, the regulation of this biosynthesis and the potential new properties of kurstakins were described in the literature. In addition, kurstakins were also detected in other species belonging to Bacillus genus such as Bacillus cereus. This mini-review gathers all the information about these promising bioactive molecules.
Disciplines :
Microbiology
Author, co-author :
Bechet, Max
Caradec, Thibault
Hussein, Walaa
Abderrahmani, Ahmed
Chollet, Marlene
Leclere, Valerie
Dubois, Thomas
Lereclus, Didier
Pupin, Maude
Jacques, Philippe ; Université de Liège - ULiège > Chimie et bio-industries > Bio-industries
Language :
English
Title :
Structure, biosynthesis, and properties of kurstakins, nonribosomal lipopeptides from Bacillus spp.
Abderrahmani A (2011) Identification du mécanisme de synthése non ribosomique d'un nouveau lipopeptide, la kurstakine et étude de son influence sur le phénotype de souches de Bacillus thuringiensis isolées en Algérie. Thése de Doctorat d'Etat, Université des Sciences et de la Technologie Houari Boumediene, Alger, Algérie
Abderrahmani A, Tapi A, Nateche F, Chollet M, Leclére V,Wathelet B, Hacene H, Jacques P (2011) Bioinformatics and molecular approaches to detect NRPS genes involved in the biosynthesis of kurstakin from Bacillus thuringiensis. Appl Microbiol Biotechnol 92:571-581
Ansari MZ, Yadav G, Gokhale RS, Mohanty D (2004) NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases. Nucleic Acids Res 32:405-413
Bachmann BO, Ravel J (2009) Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data. Methods Enzymol 458:181-217
Biria D, Maghsoudi E, Roostaazad R, Dadafarin H, Sahebghadam Lotfi A, Amoozegar MA (2010) Purification and characterization of a novel biosurfactant produced by Bacillus licheniformis MS3. World J Microbiol Biotechnol 26:871-878
Bumpus SB, Evans BS, Thomas PM, Ntai I, Kelleher NL (2009) A proteomics approach to discovering natural products and their biosynthetic pathways. Nat Biotechnol 27:951-956
Coutte F, Leclére V, Béchet M, Guez JS, Lecouturier D, Chollet-Imbert M, Dhulster P, Jacques P (2010) Effect of pps disruption and constitutive expression of srfA on surfactin productivity, spreading and antagonistic properties of Bacillus subtilis 168 derivatives. J Appl Microbiol 109:480-491
Dubois T, Faegri K, Perchat S, Lemy C, Buisson C, Nielsen-LeRoux C, Gohar M, Jacques P, Ramarao N, Kolsto AB, Lereclus D (2012) Necrotrophism is a quorum-regulated lifestyle in Bacillus thuringiensis. PloS Pathogens 8:e1002629
Fickers P, Guez JS, Damblon C, Leclére V, Béchet M, Jacques P, Joris B (2009) High-level biosynthesis of the anteiso-C(17) isoform of the antibiotic mycosubtilin in Bacillus subtilis and characterization of its candidacidal activity. Appl Environ Microbiol 75:4636-4640
Hathout Y, Ho YP, Ryzhov V, Demirev P, Fenselau C (2000) Kurstakins: a new class of lipopeptides isolated from Bacillus thuringiensis. J Nat Prod 63:1492-1496
Jacques P (2011) Surfactin and other lipopeptides from Bacillus spp. In: Soberon-Chavez G (ed) Biosurfactants microbiology monographs, vol 20. Springer, Berlin, pp 57-91
Kopp F, Marahiel MA (2007) Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis. Nat Prod Rep 24:735-749
Kraas FI, Helmetag V, Wittman M, Strieker M, Marahiel MA (2010) Functional dissection of surfactin synthetase initiation module reveals insights into the mechanism of lipoinitiation. Chem Biol 17:872-880
Leclére V, Béchet M, Adam A, Guez JS, Wathelet B, Ongena M, Thonart P, Gancel F, Chollet-Imbert M, Jacques P (2005) Mycosubtilin overproduction by Bacillus subtilis BBG100 enhances the organism's antagonistic and biocontrol activities. Appl Environ Microbiol 71:4577-4584
Madonna AJ, Voorhees KJ, Taranenko NI, Laiko VV, Doroshenko VM (2003) Detection of cyclic lipopeptide biomarkers from Bacillus species using atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry. Anal Chem 75:1628-1637
Mofid MR, Finking R, Essen L, Marahiel MA (2004) Structure-based mutational analysis of the 4'-phosphopantetheinyl transferases Sfp from Bacillus subtilis: carrier protein recognition and reaction mechanism. Biochemistry 14:4128-4136
Ongena M, Jacques P (2008) Bacillus lipopeptides: versatile weapons for plant diseases biocontrol. Trends Microbiol 16:115-125
Perchat S, Dubois T, Zouhir S, Gominet M, Poncet S, Lemy C, Aumont-Nicaise M, Deutscher J, Gohar M, Nessler S, Lereclus D (2011) A cell-cell communication system regulates protease production during sporulation in bacteria of the Bacillus cereus group. Mol Microbiol 82:619-633
Price NP, Rooney AP, Swezey JL, Perry E, Cohan FM (2007) Mass spectrometric analyses of lipopeptides from Bacillus strains isolated from diverse geographical locations. FEMSMicrobiol Lett 271:83-89
Raaijamakers JM, De Bruijn I, Nybroe O, Ongena M (2010) Natural functions of lipopeptides from Bacillus and Pseudomonas:more than surfactants and antibiotics. FEMS Microbiol Rev 34:1037-1062
Rausch C, Weber T, Kohlbacher O, Wohlleben W, Huson DH (2005) Specificity prediction of adenylation domains in nonribosomal peptide synthetases (NRPS) using Transductive Support Vector Machines (TSVM). Nucl Acids Res 33:5799-5808
Rausch C, Hoof I, Weber T, Wohlleben W, Huson DH (2007) Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution. BMC Evol Biol 7:78
Roongsawang N, Washio K, Morikawa M (2010) Diversity of nonribosomal peptide synthetases involved in the biosynthesis of lipopeptide biosurfactants. Int J Mol Sci 12:141-172
Röttig M, Medema MH, Blin K, Weber T, Rausch C, Kohlbacher O (2011) NRPSpredictor2-a web server for predicting NRPS adenylation domain specificity. Nucl Acids Res 39(Web Server issue):W362-W367
Schwarzer D, Mootz HD, Linne U, Marahiel MA (2002) Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases. Proc Natl Acad Sci USA 99:14083-14088
Sieber SA, Marahiel MA (2005) Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics. Chem Rev 105:715-738
Tapi A (2010) Stratégie moléculaire de mise en évidence de peptides actifs d'origine non ribosomiale chez Bacillus sp. et Lactobacillus sp. PhD thesis, Université Lille1 Sciences et Technologies, France
Tapi A, Chollet-Imbert M, Scherens B, Jacques P (2010) New approach for the detection of non ribosomal peptide synthetase genes in Bacillus strains by polymerase chain reaction. Appl Microbiol Biotechnol 85:1521-1531
Zeigler DR, Pragai Z, Rodriguez S, Chevreux B, Muffler A, Albert T, Bai R, Wyss M, Perkins JB (2008) The origins of 168, W23, and other Bacillus subtilis legacy strains. J Bacteriol 190:6983-6995
