Enantioseparations in nonaqueous capillary electrophoresis using charged cyclodextrins.

Alprenolol/analysis/chemistry; Bupranolol/analysis/chemistry; Electrophoresis, Capillary/methods; Flurbiprofen/analysis/chemistry; Propionates/analysis/chemistry; Stereoisomerism; Suprofen/analysis/chemistry; Temperature; Terbutaline/analysis/chemistry; Ultraviolet Rays; beta-Cyclodextrins/analysis/chemistry

Abstract :

[en] The enantioseparation of acidic and basic compounds can be successfully achieved in nonaqueous capillary electrophoresis using single-isomer charged beta-cyclodextrin (beta-CD) derivatives of opposite charge to that of the analytes. This chapter describes how to separate the enantiomers of three basic substances selected as model compounds, i.e., alprenolol, bupranolol, and terbutaline, using the negatively charged heptakis(2,3-di-O-acetyl-6-O-sulfo)-beta-CD. The enantiomers of three acidic drugs (tiaprofenic acid, suprofen, and flurbiprofen) are resolved using a monosubstituted amino beta-CD derivative, namely, 6-monodeoxy-6-mono(3-hydroxy)propylamino-beta-CD.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Servais, Anne-Catherine ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Fillet, Marianne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Language :

English

Title :

Enantioseparations in nonaqueous capillary electrophoresis using charged cyclodextrins.

Publication date :

2013

Main work title :

Methods in Molecular Biology 970: Chiral Separations

Publisher :

Springer, United States

Pages :

297-305

Available on ORBi :

since 25 September 2014

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