Reference : Transcription-coupled TA and GC strand asymmetries in the human genome
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Mathematics
Transcription-coupled TA and GC strand asymmetries in the human genome
Touchon, M. [> >]
Nicolay, Samuel mailto [Université de Liège - ULiège > Département de mathématique > Analyse - Analyse fonctionnelle - Ondelettes >]
Arneodo, Alain [> >]
d'Aubenton-Carafa [> >]
Thermes, C. [> >]
FEBS Letters
Elsevier Science
Yes (verified by ORBi)
The Netherlands
[en] Skewness ; Strand asymmetry ; Mutation bias
[en] Abstract Analysis of the whole set of human genes reveals that
most of them present TA and GC skews, that these biases are
correlated to each other and are speci¢c to gene sequences,
exhibiting sharp transitions between transcribed and non-tran-
scribed regions. The GC asymmetries cannot be explained solely
by a model previously proposed for (G+T) skew based on tran-
sitions measured in a small set of human genes. We propose that
the GC skew results from additional transcription-coupled mu-
tation process that would include transversions. During evolu-
tion, both processes acting on a large majority of genes in germ-
line cells would have produced these transcription-coupled
strand asymmetries.

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