Light modulation of human sleep depends on a polymorphism in the clock gene Period3.

[en] Non-image-forming (NIF) responses to light powerfully modulate human physiology. However, it remains scarcely understood how NIF responses to light modulate human sleep and its EEG hallmarks, and if there are differences across individuals. Here we investigated NIF responses to light on sleep in individuals genotyped for the PERIOD3 (PER3) variable-number tandem-repeat (VNTR) polymorphism. Eighteen healthy young men (20-28 years; mean+/-SEM: 25.9+/-1.2) homozygous for the PER3 polymorphism were matched by age, body-mass index, and ethnicity. The study protocol comprised a balanced cross-over design during the winter, during which participants were exposed to either light of 40lx at 6500K (blue-enriched) or light at 2500K (non-blue enriched), during 2h in the evening. Compared to light at 2500K, light at 6500K induced a significant increase in all-night NREM sleep slow-wave activity (SWA: 1.0-4.5Hz) in the occipital cortex for PER3(5/5) individuals, but not for PER3(4/4) volunteers. Dynamics of SWA across sleep cycles revealed increased occipital NREM sleep SWA for virtuallyall sleep episode only for PER3(5/5) individuals. Furthermore, they experienced light at 6500K as significantly brighter. Intriguingly, this subjective perception of brightness significantly predicted their increased occipital SWA throughout the sleep episode. Our data indicate that humans homozygous for the PER3(5/5) allele are more sensitive to NIF light effects, as indexed by specific changes in sleep EEG activity. Ultimately, individual differences in NIF light responses on sleep may depend on a clock gene polymorphism involved in sleep-wake regulation.

Disciplines :

Human health sciences: Multidisciplinary, general & others

Author, co-author :

Chellappa, Sarah Laxhmi ; Université de Liège - ULiège > Centre de recherches du cyclotron

Viola, Antoine U.

Schmidt, Christina ; Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Neuropsychologie

Bachmann, Valerie

Gabel, Virginie

Maire, Micheline

Reichert, Carolin F.

Valomon, Amandine

Landolt, Hans-Peter

Cajochen, Christian

Language :

English

Title :

Light modulation of human sleep depends on a polymorphism in the clock gene Period3.

Publication date :

2014

Journal title :

Behavioural Brain Research

ISSN :

0166-4328

eISSN :

1872-7549

Publisher :

Elsevier Science, Amsterdam, Netherlands

Volume :

271

Pages :

23-29

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 22 August 2014

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