Capillary electrophoresis-mass spectrometry, an attractive tool for drug bioanalysis and biomarker discovery

[en] The coupling of CE with MS detection, a relatively recent hyphenated technique, has gained increasing respect in the field of bioanalytical applications over the past few years. The first part of this review presents CE-MS applications dealing with drug bioanalysis, including forensic analysis and metabolism studies. Practical considerations to achieve a robust and sensitive CE-MS coupling are also presented. It is indeed essential to strictly control some critical electrospray parameters, such as the sheath liquid composition and flow rate, the nebulizing gas pressure as well as the capillary outlet position. The second part of the review critically describes the applications of CE coupled on-line to MS for the identification of biomarkers in body fluids for diagnostic purposes. Since the sample preparation procedures strongly differ according to the intended use (drug bioanalysis or biomarker discovery), they are discussed separately, taking into account the particular properties of plasma and urine matrices.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Servais, Anne-Catherine ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Crommen, Jacques ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Fillet, Marianne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Language :

English

Title :

Capillary electrophoresis-mass spectrometry, an attractive tool for drug bioanalysis and biomarker discovery

Publication date :

July 2006

Journal title :

Electrophoresis

ISSN :

0173-0835

eISSN :

1522-2683

Publisher :

Wiley-V C H Verlag Gmbh, Weinheim, Germany

Volume :

Issue :

Pages :

2616-2629

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]

Available on ORBi :

since 17 July 2009

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