[en] Here we report that grafting temperature-responsive polymers onto hyaluronic acid allows temperature-induced self-assembly into nanogels with tunable size. These nanogels can be easily loaded with hydrophobic molecules and hold potential for anti-cancer drug delivery towards human ovarian cancer cells.
Research Center/Unit :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Materials science & engineering Chemistry
Author, co-author :
Jing, Jing; Université de Grenoble, France, Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS)
Alaimo, David ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
De Vlieghere, Elly; Ghent University, Belgium, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research
Jérôme, Christine ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
De Wever, Olivier; Ghent University, Belgium, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research
De Geest, Bruno G.; Ghent University, Ghent, Belgium, Department of Pharmaceutics
Auzely-Velty, Rachel; Université de Grenoble, France, Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS)
Language :
English
Title :
Tunable self-assembled nanogels composed of well-defined thermoresponsive hyaluronic acid-polymer conjugates
Publication date :
28 August 2013
Journal title :
Journal of Materials Chemistry B
ISSN :
2050-750X
eISSN :
2050-7518
Publisher :
Royal Society of Chemistry
Volume :
1
Issue :
32
Pages :
3883-3887
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FWO - Fonds Wetenschappelijk Onderzoek Vlaanderen UGent - Universiteit Gent IUF - Institut Universitaire de France
