In vitro investigations of smart drug delivery systems based on redox-sensitive cross-linked micelles

[en] Redox-sensitive micelles are designed by using block copolymers of different architectures composed of a hydrophilic block of poly(ethylene oxide), and hydrophobic blocks of poly(ϵ-caprolactone) and poly(α-azide-ϵ-caprolactone). Stability of these micelles is insured in diluted media by cross-linking their core via the addition of a bifunctional cross-linker, while redox sensitivity is provided to these micelles by inserting a disulfide bridge in the cross-linker. The potential of these responsive micelles to be used as nanocarriers is studied in terms of cytotoxicity and cellular internalization. The release profiles are also investigated by varying the environment reductive strength.

Research Center/Unit :

Center for Education and Research on Macromolecules (CERM)

Disciplines :

Materials science & engineering
Chemistry

Author, co-author :

Cajot, Sébastien; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Schol, D.; Université de Liège - ULiège, Biomedical Sciences and Preclinical Department, Laboratory of Histology and Cytology

Dahnier, F.; Université catholique de Louvain (UCL), Brussels, Louvain Drug Research Institute (LDRI)

Préat, Véronique; Université catholique de Louvain (UCL), Brussels, Louvain Drug Research Institute (LDRI)

De Pauw-Gillet, Marie-Claire ; Université de Liège - ULiège, Biomedical Sciences and Preclinical Department, Laboratory of Histology and Cytology

Jérôme, Christine ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Language :

English

Title :

In vitro investigations of smart drug delivery systems based on redox-sensitive cross-linked micelles

Publication date :

2013

Journal title :

Macromolecular Symposia

ISSN :

1022-1360

eISSN :

1521-3900

Publisher :

Wiley, Germany

Volume :

Issue :

Pages :

1661-1670

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
FRFC - Fonds de la Recherche Fondamentale Collective
Région wallonne

Available on ORBi :

since 18 August 2014

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Bibliography

K. Van Butsele, R. Jerome, C. Jerome, Polymer 2007, 48, 7431.
G. S. Kwon, T. Okano, Adv. Drug Delivery Rev. 1996, 21, 107.
K. Kataoka, A. Harada, Y. Nagasaki, Adv. Drug Delivery Rev. 2001, 47, 113.
A. A. Gabizon, Adv. Drug Delivery Rev. 1995, 16, 285.
A. K. Iyer, G. Khaled, J. Fang, H. Maeda, Drug Discovery Today 2006, 11, 812.
H. Maeda, J. Wu, Y. Sawa, Y. Matsumura, K. Hori, J. Controlled Release 2000, 65, 271.
D. E. Owens, N. A. Peppas, Int. J. Pharm. 2006, 307, 93.
M. Belting, S. Sandgren, A. Wittrup, Adv. Drug Delivery Rev. 2005, 57, 505.
J. H. Lee, H. B. Lee, J. D. Andrade, Prog. Polym. Sci. 1995, 20, 1043.
P. Vermette, L. Meagher, Colloids Surf., B 2003, 28, 153.
S. Jaracz, J. Chen, L. V. Kuznetsova, I. Ojima, Bioorg. Med. Chem. 2005, 13, 5043.
T. M. Allen, E. Brandeis, C. B. Hansen, G. Y. Kao, S. Zalipsky, Biomembranes 1995, 1237, 99.
V. P. Torchilin, Eur. J. Pharm. Biopharm. 2008, 70, 51.
K. Van Butsele, M. Morille, C. Passirani, P. Legras, J. P. Benoit, S. K. Varshney, R. Jerome, C. Jerome, Acta Biomater. 2011, 7, 3700.
T. K. Bronich, P. A. Keifer, L. S. Shlyakhtenko, A. V. Kabanov, J. Am. Chem. Soc. 2005, 127, 8236.
X. Hu, X. Chen, J. Wei, S. Liu, X. Jing, Macromol. Biosci. 2009, 9, 456.
M. Sandholzer, S. Bichler, F. Stelzer, C. Slugovc, J. Polym. Sci., Part A 2008, 46, 2402.
A. Meister, M. E. Anderson, Ann. Rev. Biochem. 1983, 52, 711.
Y. Wang, P. Chen, J. Shen, Biomaterials 2006, 27, 5292.
S. Cajot, P. Lecomte, C. Jérôme, R. Riva, Polym. Chem. 2013, 4, 1025.
S. Cajot, N. Lautram, C. Passirani, C. Jerome, J. Controlled Release 2011, 152, 30.
P. Vangeyte, S. Gautier, R. Jerome, Colloids Surf., A: Physicochem. Eng. Aspects 2004, 242, 203.
J. Rieger, C. Passirani, J.-P. Benoit, K. Van Butsele, R. Jerome, C. Jerome, Adv. Funct. Mater. 2006, 16, 1506.
C. Allen, Y. Yu, D. Maysinger, A. Eisenberg, Bioconjugate Chem. 1998, 9, 564.
W.-J. Lin, Y.-C. Chen, C.-C. Lin, C.-F. Chen, J.-W. Chen, J. Biomed. Mater. Res., Part B: Appl. Biomater. 2006, 77B, 188.
K. Kunath, A. von Harpe, H. Petersen, D. Fischer, K. Voigt, T. Kissel, U. Bickel, Pharm. Res. 2002, 19, 810.
D. Fischer, Y. Li, B. Ahlemeyer, J. Krieglstein, T. Kissel, Biomaterials 2003, 24, 1121.
C. Allen, Y. Yu, A. Einsenberg, D. Maysinger, Biochim. Biophys. Acta Biomembr. 1999, 1421, 32.
R. M. Sawant, J. P. Hurley, S. Salmaso, A. Kale, E. Tolcheva, T. S. Levchenko, V. P. Torchilin, Bioconjugate Chem. 2006, 17, 943.
J. Gu, W.-P. Cheng, J. Liu, S.-Y. Lo, D. Smith, X. Qu, Z. Yang, Biomacromolecules 2008, 9, 255.