[en] Redox-sensitive micelles are designed by using block copolymers of different architectures composed of a hydrophilic block of poly(ethylene oxide), and hydrophobic blocks of poly(ϵ-caprolactone) and poly(α-azide-ϵ-caprolactone). Stability of these micelles is insured in diluted media by cross-linking their core via the addition of a bifunctional cross-linker, while redox sensitivity is provided to these micelles by inserting a disulfide bridge in the cross-linker. The potential of these responsive micelles to be used as nanocarriers is studied in terms of cytotoxicity and cellular internalization. The release profiles are also investigated by varying the environment reductive strength.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Materials science & engineering Chemistry
Author, co-author :
Cajot, Sébastien; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Schol, D.; Université de Liège - ULiège, Biomedical Sciences and Preclinical Department, Laboratory of Histology and Cytology
Dahnier, F.; Université catholique de Louvain (UCL), Brussels, Louvain Drug Research Institute (LDRI)
Préat, Véronique; Université catholique de Louvain (UCL), Brussels, Louvain Drug Research Institute (LDRI)
De Pauw-Gillet, Marie-Claire ; Université de Liège - ULiège, Biomedical Sciences and Preclinical Department, Laboratory of Histology and Cytology
Jérôme, Christine ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
In vitro investigations of smart drug delivery systems based on redox-sensitive cross-linked micelles
Publication date :
2013
Journal title :
Macromolecular Symposia
ISSN :
1022-1360
eISSN :
1521-3900
Publisher :
Wiley, Germany
Volume :
13
Issue :
12
Pages :
1661-1670
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE] BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique FRFC - Fonds de la Recherche Fondamentale Collective [BE] Région wallonne [BE]
