Article (Scientific journals)
Radiation therapy duration influences overall survival in patients with cervix carcinoma.
Coucke, Philippe; Delaloye, J-F; Pampallona, S et al.
1997In International Journal of Gynecology and Obstetrics, 57, p. 295-303
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Keywords :
Treatment time; Overrall survival; radiation therapy; cervical carcinoma
Abstract :
[en] of the cervix treated by radical radiation therapy. Method; Three hundred and sixty patients with FIG0 stage IB-IIIB carcinoma of the cervix were treated in Lausanne (Switzerland) with external radiation and brachytherapy as first line therapy. Median therapy duration was 45 days. Patients were classified according to the duration of the therapies, taking 60 days (the 75th percentile) as an arbitrary cut-off. Results: The 5-year survival was 61% (SE. = 3%) for the therapy duration group of less than 60 days and 53% (SE. = 7%) for the group of more than 60 days. In terms of univariate hazard ratio (HR), the relative difference between the hvo groups corresponds to a 50% increase of deaths (HR = 1.53, 95% CI = 1.03-2.28) for the longer therapy duration group (P = 0.044). In a multivariate analysis, the magnitude of estimated relative hazards for the longer therapies are confirmed though significance was reduced (HR = 1.52, 95% CI = 0.94-2.45, P = 0.084). Conclusion: These findings suggesthat short treatment duration is a factor associated with longer survival in carcinoma of the cervix. 0 1997 International Federation of Gynecology and Obstetrics
Disciplines :
Hematology
Oncology
Author, co-author :
Coucke, Philippe  ;  Centre Hospitalier Universitaire Vaudois > Radio-Oncologie > Lausanne, SUISSE
Delaloye, J-F
Pampallona, S
Peltecu, G
De Grandi, P
Language :
English
Title :
Radiation therapy duration influences overall survival in patients with cervix carcinoma.
Publication date :
1997
Journal title :
International Journal of Gynecology and Obstetrics
ISSN :
0020-7292
eISSN :
1879-3479
Publisher :
Elsevier, Limerick, Ireland
Volume :
57
Pages :
295-303
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 15 July 2009

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