Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial.

Henrotin, Yves

doi:10.1186/1472-6882-14-159

Article (Scientific journals)

Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial.

Henrotin, Yves

2014 • In BMC Complementary and Alternative Medicine

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/169905

DOI
10.1186/1472-6882-14-159

PubMed
24886572

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Keywords :

osteoarthritis; therapy; cartilage

Abstract :

[en] The management of osteoarthritis (OA) remains a challenge. There is a need not only for safe and efficient treatments but also for accurate and reliable biomarkers that would help diagnosis and monitoring both disease activity and treatment efficacy. Curcumin is basically a spice that is known for its anti-inflammatory properties. In vitro studies suggest that curcumin could be beneficial for cartilage in OA. The aim of this exploratory, non-controlled clinical trial was to evaluate the effects of bio-optimized curcumin in knee OA patients on the serum levels of specific biomarkers of OA and on the evaluation of pain. This study highlighted the potential effect of curcumin in knee OA patient. This effect was reflected by the variation of a cartilage specific biomarker, Coll2-1 that was rapidly affected by the treatment. These results are encouraging for the qualification of Coll2-1 as a biomarker for the evaluation of curcumin in OA treatment. (Trial registration: NCT01909037 at clinicaltrials.gov)

Disciplines :

Rheumatology

Author, co-author :

Henrotin, Yves ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.)

Language :

English

Title :

Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial.

Publication date :

2014

Journal title :

BMC Complementary and Alternative Medicine

eISSN :

1472-6882

Publisher :

BioMed Central

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 05 July 2014

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