Article (Scientific journals)
Basic rules of dosimetry in endovascular brachytherapy.
Coucke, Philippe; PHUOC DO, Hu; Pica, Alessia et al.
2000In Journal of Interventional Cardiology, 13 (6), p. 425-429
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Keywords :
radiotherapy; endovascular; brachytherapy; PCI; restenosis
Abstract :
[en] Endovascular brachytherapy after percutaneous coronary intervention (PCI), is becoming a standard approach for the treatment and prevention of restenosis. A variety of technical approaches are currently available to deliver ionizing irradiation to the vascular target. Basically two kinds of radioactive isotopes are available that emit gamma radiation (photons) or beta radiation (electrons). The pitfalls and solutions for the optimization of dosimetry are discussed. As might be expected, the inhomogeneous dose distribution across the target volume results in recurrence by underdosage or in complications because of overdosage. Moreover, uniformization of the target definition and reporting of the dose distribution in endovascular brachytherapy is a prerequisite for comparison between the results of the various clinical trials and is absolutely necessary to improve the therapeutic efficacy of this new approach in the prevention of restenosis after coronary angioplasty with or without stenting. (J Interven Cardiol2000; 13:425430)
Disciplines :
Hematology
Oncology
Author, co-author :
Coucke, Philippe  ;  Radiation Oncology > Lausanne, Switzerland
PHUOC DO, Hu;  Institut de Radiophysique Appliquée > Lausanne, Switzerland
Pica, Alessia;  Radiation Oncology > Lausanne, Switzerland
Urban, Filip;  Centre Hospitalier Universitaire Vaudois > Division of Cardiology, Department of Medicine > Lausanne, Switzerland
Pache, Gilbert;  Institut de Radiophysique Appliquée > Lausanne, Switzerland
Language :
English
Title :
Basic rules of dosimetry in endovascular brachytherapy.
Publication date :
2000
Journal title :
Journal of Interventional Cardiology
ISSN :
0896-4327
eISSN :
1540-8183
Publisher :
Blackwell Publishing
Volume :
13
Issue :
6
Pages :
425-429
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 15 July 2009

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