Radiation-associated synovial-sarcoma: clinicopathological and molecular analysis of two cases.

[en] Development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant peripheral nerve sheath tumors, and angiosarcomas are most frequently encountered. Radiationassociated synovial sarcomas are exceptional. We report the clinicopathologic, immunohistochemical, and molecular features of two radiationassociated synovial sarcomas. One tumor developed in a 42-year-old female 17 years after external irradiation was given for breast carcinoma; the other occurred in a 34-year-old female who was irradiated at the age of 7 years for a nonneoplastic condition of the left hand. Both lesions showed morphologic features of monophasic spindle cell synovial sarcoma, were immunoreactive for cytokeratins, epithelial membrane antigen, CD99, CD117 (c-kit), and bcl-2 and bore the t(X;18) (SYT-SSX1) translocation. We conclude that synovial sarcoma has to be added to the list of radiation-associated soft-tissue sarcomas. Mod Pathol 2002;15(9):998–1004

Disciplines :

Oncology
Hematology

Author, co-author :

Egger, J-F; university hospital lausane

Coindre, J-M; university hospital lausane

Benhattar, J

COUCKE, Philippe ; university hospital lausane > Radiothérapie

Guillou, L; university hospital lausane

Language :

English

Title :

Radiation-associated synovial-sarcoma: clinicopathological and molecular analysis of two cases.

Publication date :

2002

Journal title :

Modern Pathology

ISSN :

0893-3952

eISSN :

1530-0285

Publisher :

Lippincott Williams & Wilkins, Hagerstown, United States - Maryland

Volume :

Issue :

Pages :

998-1004

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 15 July 2009

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Bibliography

Fisher C. (1998) Synovial sarcoma. Ann Diagn Pathol 2:401-421.
Weiss S.W., Goldblum J.R. Enzinger and Weiss's soft tissue tumors. 4th ed. , St. Louis: Mosby; 2001, 1483-1571.
Lasota J., Jasinski M., Debiec-Rychter M., Szadowska A., Limon J., Miettinen M. (1998) Detection of the SYT-SSX fusion transcripts in formaldehyde-fixed, paraffin-embedded tissue: A reverse transcription polymerase chain reaction amplification assay useful in the diagnosis of synovial sarcoma. Mod Pathol 11:626-633.
Argani P., Zakowski M.F., Klimstra D.S., Rosai J., Ladanyi M. (1998) Detection of the SYT-SSX chimeric RNA of synovial sarcoma in paraffin-embedded tissue and its application in problematic cases. Mod Pathol 11:65-71.
Van de Rijn M., Barr F.G., Collins M.H., Xiong Q.B., Fisher C. (1999) Absence of SYT-SSX fusion products in soft tissue tumors other than synovial sarcoma. Am J Clin Pathol 112:43-49.
Guillou L., Coindre J.M., Gallagher G., Terrier P., Gebhard S., De Saint Aubain Somerhausen N. (2001) Detection of the synovial sarcoma translocation t(X; 18) (SYT; SSX) in paraffin-embedded tissues using RT-PCR: A reliable and powerful diagnostic tool for pathologists. A molecular analysis of 221 mesenchymal tumors fixed in different fixatives. Hum Pathol 32:105-112.
Mark R.J., Poen J., Tran L.M. (1993) Postirradiation sarcomas: A single institution study and review of the literature. Cancer 73:2653-2662.
Robinson E., Neugut A.I., Wylie P. (1988) Clinical aspects of postirradiation sarcomas. J Natl Cancer Inst 80:233-240.
Wiklund T.A., Blomqvist C.P., Raty J., Elomaa I., Rissanen P., Miettinen M. (1991) Postirradiation sarcoma. Analysis of a nationwide cancer registry material. Cancer 68:524-531.
Murray E.M., Werner D., Greeff E.A., Taylor D.A. (1999) Postradiation sarcomas: 20 Cases and a literature review. Int J Radiat Oncol Biol Phys 45:951-961.
Amendola B.E., Amendola M.A., McClatchey K.D., Miller C.H. (1989) Radiation-associated sarcoma: A review of 23 patients with postradiation sarcoma over a 50-year period. Am J Clin Oncol 12:411-415.
Laskin W.B., Silverman T.A., Enzinger F.M. (1988) Postradiation soft tissue sarcomas. An analysis of 53 cases. Cancer 62:2330-2340.
Kim J.H., Chu F.C., Woodard H.Q., Melamed M.R., Huvos A., Cantin J. (1978) Radiation-induced soft-tissue and bone sarcoma. Radiology 129:501-508.
Lagrange J.L., Ramaioli A., Chateau M.C., Marchal C., Resbeut M., Richaud P. (2000) Sarcoma after radiation therapy: Retrospective multiinstitutional study of 80 histologically confirmed cases. Radiology , Radiation therapist and pathologist groups of the Federation Nationale des Centres de Lutte Contre le Cancer; 216:197-205.
Inoue Y.Z., Frassica F.J., Sim F.H., Unni K.K., Petersen I.A., McLeod R.A. (2000) Clinicopathologic features and treatment of postirradiation sarcoma of bone and soft tissue. J Surg Oncol 75:42-50.
Bloechle C., Peiper M., Schwarz R., Schroeder S., Zornig C. (1995) Postirradiation soft tissue sarcoma. Eur J Cancer 31:31-34.
Mischler N.E., Chuprevich T., Tormey D.C., Ramirez G., Mack E.A. (1978) Synovial sarcoma of the neck associated with previous head and neck radiation therapy. Arch Otolaryngol 104:482-483.
Van de Rijn M., Barr F.G., Xiong Q.B., Salhany K.E., Fraker D.L., Fisher C. (1997) Radiation-associated synovial sarcoma. Hum Pathol 28:1325-1328.
Weiss S.W. (1994) Histological typing of soft tissue tumours. International histological classification of soft tissue tumours. 2nd ed., Sobin LH, editor. Berlin: Springer-Verlag; .
Hsu S.M., Raine L., Fanger H. (1981) Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabelled antibody (PAP) procedures. J Histochem Cytochem 29:577-580.
Guillou L., Wadden C., Kraus M.D., Dei Tos A.P., Fletcher C.D.M. (1996) S100 protein activity in synovial sarcoma. A potentially frequent diagnostic pitfall. Immunohistochemical analysis of 100 cases. Appl Immunohistochem 4:167-175.
Kawai A., Woodruff J., Healey J.H., Brennan M.F., Antonescu C.R., Ladanyi M. (1998) SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N Engl J Med 338:153-160.
Miettinen M., Lasota J. (2001) Gastrointestinal stromal tumors. Definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch 438:1-12.
Ricotti E., Fagioli F., Garelli E., Linari C., Crescenzio N., Horenstein A.L. (1998) C-kit is expressed in soft tissue sarcoma of neuroectodermic origin and its ligand prevents apoptosis of neoplastic cells. Blood 91:2397-2405.
Tamborini E., Papini D., Mezzelani A., Riva C., Azzarelli A., Sozzi G. (2001) C-kit and c-kit ligand (SCF) in synovial sarcoma (SS): An mRNA expression analysis in 23 cases. Br J Cancer 85:405-411.
Smith T.A., Machen S.K., Fisher C., Goldblum J.R. (1999) Usefulness of cytokeratin subsets for distinguishing monophasic synovial sarcoma from malignant peripheral nerve sheath tumor. Am J Clin Pathol 112:641-648.
O'Sullivan M.J., Kyriakos M., Zhu X., Wick M.R., Swanson P.E., Dehner L.P. (2000) Malignant peripheral nerve sheath tumors with t(X; 18). A pathologic and molecular genetic study. Mod Pathol 13:1236-1246.
Ladanyi M., Woodruff J.M., Scheithauer B.W., Bridge J.A., Barr F.G., Goldblum J.R. (2001) Letter to the editor. Mod Pathol 14:733-735.