Radiation-associated synovial-sarcoma: clinicopathological and molecular analysis of two cases.

[en] Development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant peripheral nerve sheath tumors, and angiosarcomas are most frequently encountered. Radiationassociated synovial sarcomas are exceptional. We report the clinicopathologic, immunohistochemical, and molecular features of two radiationassociated synovial sarcomas. One tumor developed in a 42-year-old female 17 years after external irradiation was given for breast carcinoma; the other occurred in a 34-year-old female who was irradiated at the age of 7 years for a nonneoplastic condition of the left hand. Both lesions showed morphologic features of monophasic spindle cell synovial sarcoma, were immunoreactive for cytokeratins, epithelial membrane antigen, CD99, CD117 (c-kit), and bcl-2 and bore the t(X;18) (SYT-SSX1) translocation. We conclude that synovial sarcoma has to be added to the list of radiation-associated soft-tissue sarcomas. Mod Pathol 2002;15(9):998–1004

Disciplines :

Oncology
Hematology

Author, co-author :

Egger, J-F; university hospital lausane

Coindre, J-M; university hospital lausane

Benhattar, J

COUCKE, Philippe ; university hospital lausane > Radiothérapie

Guillou, L; university hospital lausane

Language :

English

Title :

Radiation-associated synovial-sarcoma: clinicopathological and molecular analysis of two cases.

Publication date :

2002

Journal title :

Modern Pathology

ISSN :

0893-3952

eISSN :

1530-0285

Publisher :

Lippincott Williams & Wilkins, Hagerstown, United States - Maryland

Volume :

Issue :

Pages :

998-1004

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 15 July 2009

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