Radiation-associated synovial-sarcoma: clinicopathological and molecular analysis of two cases.

Egger, J-F; Coindre, J-M; Benhattar, J; COUCKE, Philippe; Guillou, L

doi:10.1097/01.MP.0000026616.41545.FF

Reference : Radiation-associated synovial-sarcoma: clinicopathological and molecular analysis of ...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Hematology Human health sciences : Oncology
	To cite this reference:	http://hdl.handle.net/2268/16980

Title :	Radiation-associated synovial-sarcoma: clinicopathological and molecular analysis of two cases.
Language :	English
Author, co-author :	Egger, J-F [university hospital lausane > > > >]
	Coindre, J-M [university hospital lausane > > > >]
	Benhattar, J [ > > ]
	COUCKE, Philippe [university hospital lausane > > Radiothérapie > > >]
	Guillou, L [university hospital lausane > > > >]
Publication date :	2002
Journal title :	Modern Pathology : An Official Journal of the United States & Canadian Academy of Pathology, Inc
Publisher :	Lippincott Williams & Wilkins
Volume :	15
Issue/season :	9
Pages :	998-1004
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0893-3952
e-ISSN :	1530-0285
City :	Hagerstown
Country :	MD
Keywords :	[en] Cytogenetics ; Molecular biology ; Pathology ; Radiation-associated sarcoma ; Radiation ; therapy, RT-PCR
	[fr] Synovial sarcoma, ; Translocation
Abstract :	[en] Development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant peripheral nerve sheath tumors, and angiosarcomas are most frequently encountered. Radiationassociated synovial sarcomas are exceptional. We report the clinicopathologic, immunohistochemical, and molecular features of two radiationassociated synovial sarcomas. One tumor developed in a 42-year-old female 17 years after external irradiation was given for breast carcinoma; the other occurred in a 34-year-old female who was irradiated at the age of 7 years for a nonneoplastic condition of the left hand. Both lesions showed morphologic features of monophasic spindle cell synovial sarcoma, were immunoreactive for cytokeratins, epithelial membrane antigen, CD99, CD117 (c-kit), and bcl-2 and bore the t(X;18) (SYT-SSX1) translocation. We conclude that synovial sarcoma has to be added to the list of radiation-associated soft-tissue sarcomas. Mod Pathol 2002;15(9):998–1004
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/16980
DOI :	10.1097/01.MP.0000026616.41545.FF

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