Reference : Radiation-associated synovial-sarcoma: clinicopathological and molecular analysis of ...
Scientific journals : Article
Human health sciences : Hematology
Human health sciences : Oncology
Radiation-associated synovial-sarcoma: clinicopathological and molecular analysis of two cases.
Egger, J-F [university hospital lausane > > > >]
Coindre, J-M [university hospital lausane > > > >]
Benhattar, J [ > > ]
COUCKE, Philippe mailto [university hospital lausane > > Radiothérapie > > >]
Guillou, L [university hospital lausane > > > >]
Modern Pathology : An Official Journal of the United States & Canadian Academy of Pathology, Inc
Lippincott Williams & Wilkins
Yes (verified by ORBi)
[en] Cytogenetics ; Molecular biology ; Pathology ; Radiation-associated sarcoma ; Radiation ; therapy, RT-PCR
[fr] Synovial sarcoma, ; Translocation
[en] Development of a soft-tissue sarcoma is an infrequent
but well-known long-term complication of
radiotherapy. Malignant fibrous histiocytomas, extraskeletal
osteosarcomas, fibrosarcomas, malignant
peripheral nerve sheath tumors, and angiosarcomas
are most frequently encountered. Radiationassociated
synovial sarcomas are exceptional. We
report the clinicopathologic, immunohistochemical,
and molecular features of two radiationassociated
synovial sarcomas. One tumor developed
in a 42-year-old female 17 years after external irradiation
was given for breast carcinoma; the other
occurred in a 34-year-old female who was irradiated
at the age of 7 years for a nonneoplastic condition of
the left hand. Both lesions showed morphologic features
of monophasic spindle cell synovial sarcoma,
were immunoreactive for cytokeratins, epithelial
membrane antigen, CD99, CD117 (c-kit), and bcl-2
and bore the t(X;18) (SYT-SSX1) translocation. We
conclude that synovial sarcoma has to be added to
the list of radiation-associated soft-tissue sarcomas.
Mod Pathol 2002;15(9):998–1004
Researchers ; Professionals

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