Adkins J.C., Noble S. Tiagabine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the management of epilepsy. Drugs. 55:1998;437-460.
Ben-Ari Y., Cherubini E., Corradetti R., Gaiarsa J.-L. Giant synaptic potentials in immature rat CA3 hippocampal neurons. J. Physiol. (London). 416:1988;303-325.
Borden L.A., Dhar T.G.M., Smith K.E., Weinshank R.L., Branchek T.A., Gluchowski C. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selctive for the cloned GABA transporter GAT-1. Eur. J. Pharmacol., Mol. Pharmacol. 269:1994;219-224.
Brady R.J., Smitch K.L., Swann J.W. Calcium modulation of the N-methyl-D-aspartate (NMDA) response and electrographic seizures in immature hippocampus. Neurosci. Lett. 124:1991;92-96.
Draguhn A., Heinemann U. Different mechanisms regulate IPSC kinetics in early postnatal and juvenile hippocampal granule cells. J. Neurophysiol. 76:1996;3983-3993.
Engel D., Schmitz D., Gloveli T., Frahm C., Heinemann U., Draguhn A. Laminar differences in GABA-uptake and GAT-1 expression in rat CA1. J. Physiol. (London). 512:1998;643-649.
Evans J.E., Frostholm A., Rotter A. Embryonic and postnatal expression of four gamma-aminobutyric acid transporter mRNAs in the mouse brain and leptomeninges. J. Comp. Neurol. 376:1996;431-436.
Faingold C.L., Randall M.E., Anderson C.A. Blockade of GABA uptake with tiagabine inhibits audiogenic seizures and reduces neuronal firing in the inferior colliculus of the genetically epilepsy-prone rat. Exp. Neurol. 126:1994;225-232.
Garant D.S., Xu S.G., Sperber E.F., Moshé S.L. Age-related differences in the effects of GABAA agonists microinjected into rat substantia nigra: pro- and anticonvulsant actions. Epilepsia. 36:1995;960-965.
Gloveli T., Albrecht D., Heinemann U. Properties of low Mg2+ induced epileptiform activity in rat hippocampal and entorhinal cortex slices during adolescence. Dev. Brain Res. 87:1995;145-152.
Gonsalves S.F., Twitchell B., Harbraugh R.E., Krogsgard-Larson P., Schousbou A. Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures. Eur. J. Pharmacol. 168:1989;265-268.
Gram L. Tiagabine: a novel drug with a GABAergic mechanism of action. Epilepsia. 35(Suppl. 5):1994;S85-S87.
Guastella J., Nelson N., Nelson H., Czychek L., Keynan S., Miedel M.C., Davidson N., Lester H.A., Kanner B.I. Cloning and expression of a rat brain GABA transporter. Science. 249:1990;1303-1306.
Hablitz J.J., Heinemann U. Extracellular K+ and Ca2+ changes during epileptiform discharges in the immature rat neocortex. Dev. Brain Res. 36:1987;299-303.
Houser C.R., Esclapez M. Localization of mRNAs encoding two forms of glutamic acid decarboxylase in the rat hippocampal formation. Hippocampus. 4:1994;530-545.
Kriegstein A.R., Suppes T., Prince D.A. Cellular and synaptic physiology and epileptogenesis of developing rat neocortical neurons in vitro. Dev. Brain Res. 34:1987;161-171.
Lambolez B., Audinat E., Bochet P., Crepel F., Rossier J. AMPA receptor subunits expressed by single Purkinje-cells. Neuron. 9:1992;247-258.
Lehmenkühler A., Sykova E., Svoboda J., Zilles K., Nicholson C. Extracellular space parameters in rat neocortex and subcortical white matter during postnatal development determinated by diffusion analysis. Neuroscience. 55:1993;339-351.
Lothman E.W., Bertram E.H. III Epileptogenic effects of status epilepticus. Epilepsia. 34(Suppl. 1):1993;59-70.
Luer M.S., Rhoney D.H. Tiagabine: a novel antiepileptic drug. Ann. Pharmacother. 32:1998;1173-1180.
Moshé S.L., Albala B.J., Ackermann R.F., Engel J. III Increased seizure susceptibility of the immature brain. Dev. Brain Res. 7:1983;81-85.
Oh D.J., Dichter M.A. Effect of a gamma-aminobutyric acid uptake inhibitor, NNC-711, on spontaneous postsynaptic currents in cultured rat hippocampal neurons: implications for antiepileptic drug development. Epilepsia. 35:1994;426-430.
Pfeiffer M., Draguhn A., Meierkord H., Heinemann U. Effects of γ-aminobutyric acid (GABA) agonists and GABA uptake inhibitors on pharmacosensitive and pharmacoresistant epileptiform activity in vitro. Br. J. Pharmacol. 119:1996;569-577.
Polásek R., Kubová H., Slamberová R., Mares P., Vorlícek J. Suppression of cortical epileptic afterdischarges in developing rats by anticonvulsants increasing GABAergic inhibition. Epilepsy Res. 25:1996;177-184.
Rekling J.C., Jahnsen H., Mosfeldt Laursen A. The effect of two lipophilic γ-aminobutyric acid uptake blockers in CA1 of the rat hippocampal slice. Br. J. Pharmacol. 99:1990;103-106.
Ribak C.E., Tong W.M.-Y., Brecha N.C. GABA plasma membrane transporters, GAT-1 and GAT-3, display different distributions on the rat hippocampus. J. Comp. Neurol. 367:1996;595-606.
Richens A., Chadwick D.W., Duncan J.S., Dam M., Gram L., Mikkelsen M., Morrow J., Mengel H., Shu V., McMelvy J.F., Peirce M.W. Adjunctive treatment of partial seizures with tiagabine: a placebo-controlled trial. Epilepsy Res. 21:1995;37-42.
Roepstorff A., Lambert J.D.C. Factors contributing to the decay of the stimulus-evoked IPSCs in rat hippocampal CA1 neurons. J. Neurophysiol. 72:1994;2911-2926.
Schousbou A., Larsson O.M., Wood J.D., Krogsgaard-Larson P. Transport and metabolism of γ-aminobutyric acid in neurons and glia: implications for epilepsy. Epilepsia. 24:1983;531-538.
Smith S.E., Parvez N.S., Chapman A.G., Meldrum B.S. The γ-aminobutyric acid uptake inhibitor, tiagabine, is anticonvulsant in two animal models of reflex epilepsy. Eur. J. Pharmacol. 273:1995;259-265.
Suzdak P.D. Lack of tolerance to the anticonvulsant effects of tiagabine following chronic (21 day) treatment. Epilepsy Res. 19:1994;205-213.
Suzdak P.D., Jansen J.A. A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor. Epilepsia. 36:1995;612-626.
Swann J.W., Smith K.L., Brady R.J. Localized excitatory synaptic interactions mediate the sustained depolarization of electrographic seizures in developing hippocampus. J. Neurosci. 13:1993;4680-4689.
Thompson S.M., Gähwihler B.H. Effects of the GABA uptake inhibitor tiagabine on inhibitory synaptic potentials in rat hippocampal slice cultures. J. Neurophysiol. 67:1992;1698-1701.
Veliskova J., Löscher W., Moshé S.L. Regional and age specific effects of zolpidem microinfusions in the substantia nigra on seizures. Epilepsy Res. 30:1998;107-114.
Walton N.Y., Gunawan S., Treiman D.M. Treatment of experimental status epilepticus with the GABA uptake inhibitor, tiagabine. Epilepsy Res. 19:1994;237-244.
Whittington M.A., Traub R.D., Jefferys J.G.R. Erosion of inhibition contributes to the progression of low magnesium bursts inrat hippocampal slice. J. Physiol. 486:1995;723-734.
Zhang C., Dreier J., Heinemann U. Paroxysmal epileptiform discharges in temporal lobe slices after prolonged exposure to low magnesium are resistant to clinically used anticonvulsants. Epilepsy Res. 20:1995;105-111.