Article (Scientific journals)
A Hand Immersion Test under Laboratory-Controlled Usage Conditions: The Need for Sensitive and Controlled Assessment Methods
Paye, Marc; Gomes, G.; Zerweck, C. R. et al.
1999In Contact Dermatitis, 40 (3), p. 133-8
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Abstract :
[en] Exaggerated test conditions were frequently used to investigate the cutaneous tolerance of detergent products in the past. As the sensitivity of newly designed biometric methods is steadily improving, the trend towards more realistic test conditions should be encouraged. A hand immersion test under laboratory-controlled usage conditions is presently described, fulfilling such principles. Panelists soaked their hands in 2 different hand dishwashing liquids, 2x daily for 10 min each (with successive in-solution/out-of-solution cycles) for 4 consecutive days. Products were at usual dilution for dishwashing liquids and were randomized between the dominant and non-dominant hands of panelists. Visual scoring of erythema and dryness developing on the whole hands (scoring scales including interdigital areas and joints) during the week did not allow discrimination between the 2 products. However the dominant hands were significantly more susceptible to alterations than the non-dominant hands, regardless of product attribution. In contrast, skin electrical measurements (Corneometer CM800 and Skicon 200) on the dorsum of the hands (muscle mass between thumb and index) and squamometry analysis of tape stripping (harvested from the same site) yielded significant differences between the 2 products. In conclusion, a hand immersion test under realistic conditions has been described, which discriminates between products when sensitive assessment methods are used to explore skin sites partially protected from daily-life skin aggressions.
Disciplines :
Dermatology
Author, co-author :
Paye, Marc ;  Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Gomes, G.
Zerweck, C. R.
Pierard, Gérald ;  Université de Liège - ULiège > Département des sciences cliniques > Dermatopathologie
Grove, G. L.
Language :
English
Title :
A Hand Immersion Test under Laboratory-Controlled Usage Conditions: The Need for Sensitive and Controlled Assessment Methods
Publication date :
March 1999
Journal title :
Contact Dermatitis
ISSN :
0105-1873
eISSN :
1600-0536
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
40
Issue :
3
Pages :
133-8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 June 2014

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