Reference : Mechanisms of reduced implant stability in osteoporotic bone
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
Life sciences : Biochemistry, biophysics & molecular biology
Mechanisms of reduced implant stability in osteoporotic bone
Ruffoni, Davide mailto [Université de Liège - ULiège > Département d'aérospatiale et mécanique > Mécanique des matériaux biologiques et bioinspirés >]
Mueller, R. [Swiss Fed Inst Technol, Inst Biomech, Zurich, Switzerland.]
van Lenthe, G. H. [Swiss Fed Inst Technol, Inst Biomech, Zurich, Switzerland.]
Biomechanics and Modeling in Mechanobiology
Springer Heidelberg
Yes (verified by ORBi)
[en] Implant anchorage ; Peri-implant bone architecture ; Osteoporosis ; Finite element method ; Pull-out test
[en] The determining factors for the fixation of uncemented screws in bone are the bone-implant interface and the peri-implant bone. The goal of this work was to explore the role of the peri-implant bone architecture on the mechanics of the bone-implant system. In particular, the specific aims of the study were to investigate: (i) the impact of the different architectural parameters, (ii) the effects of disorder, and (iii) the deformations in the peri-implant region. A three-dimensional beam lattice model to describe trabecular bone was developed. Various microstructural features of the lattice were varied in a systematic way. Implant pull-out tests were simulated, and the stiffness and strength of the bone-implant system were computed. The results indicated that the strongest decrease in pull-out strength was obtained by trabecular thinning, whereas pull-out stiffness was mostly affected by trabecular removal. These findings could be explained by investigating the peri-implant deformation field. For small implant displacements, a large amount of trabeculae in the peri-implant region were involved in the load transfer from implant to bone. Therefore, trabecular removal in this region had a strong negative effect on pull-out stiffness. Conversely, at higher displacements, deformations mainly localized in the trabeculae in contact with the implant; hence, thinning those trabeculae produced the strongest decrease in the strength of the system. Although idealized, the current approach is helpful for a mechanical understanding of the role played by peri-implant bone.
AO Foundation [CPP1]
This research was funded by the AO Foundation (network grant CPP1).

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