Reference : Mitochondrial UCPs: New insights into regulation and impact
Scientific congresses and symposiums : Paper published in a journal
Life sciences : Biochemistry, biophysics & molecular biology
Mitochondrial UCPs: New insights into regulation and impact
Sluse, Francis mailto [Université de Liège - ULiège > Département des sciences de la vie > Bioénergétique et physiologie cellulaire >]
Jarmuszkiewicz, Wieslawa [> > > >]
Navet, Rachel mailto [Université de Liège - ULiège > > GIGA - Formation >]
Douette, Pierre [Université de Liège - ULiège > > Bioénergétique et physiologie cellulaire >]
Mathy, Grégory [Université de Liège - ULiège > Département des sciences de la vie > Bioénergétique et physiologie cellulaire >]
Sluse-Goffart, Claudine M [> > > >]
Biochimica et Biophysica Acta-Bioenergetics
Elsevier Science Bv
5-6, Suppl 1
Yes (verified by ORBi)
14th European Bioenergetics Conference
22/27 Juillet 2006
[en] Mitochondria ; Uncoupling protein
[en] Uncoupling proteins (UCPs) are mitochondrial inner membrane proteins sustaining an inducible proton conductance. They weaken the proton electrochemical gradient built up by the mitochondrial respiratory chain. Brown fat UCP1 sustains a free fatty acid (FA)-induced purine nucleotide (PN)-inhibited proton conductance. Inhibition of the proton conductance by PN has been considered as a diagnostic of UCP activity. However, conflicting results have been obtained in isolated mitochondria for UCP homologues (i.e., UCP2, UCP3, plant UCP, and protist UCP) where the FFA-activated proton conductance is poorly sensitive to PN under resting respiration conditions. Our recent work clearly indicates that the membranous coenzyme Q, through its redox state, represents a regulator of the inhibition by PN of FFA-activated UCP1 homologues under phosphorylating respiration conditions. Several physiological roles of UCPs have been suggested, including a control of the cellular energy balance as well as the preventive action against oxidative stress. In this paper, we discuss new information emerging from comparative proteomics about the impact of UCPs on mitochondrial physiology, when recombinant UCP1 is expressed in yeast and when UCP2 is over-expressed in hepatic mitochondria during steatosis
Fonds de la Recherche Fondamentale Collective d’Initiative des Chercheurs - FRFC
Researchers ; Students

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