Mitochondrial UCPs: New insights into regulation and impact

[en] Uncoupling proteins (UCPs) are mitochondrial inner membrane proteins sustaining an inducible proton conductance. They weaken the proton electrochemical gradient built up by the mitochondrial respiratory chain. Brown fat UCP1 sustains a free fatty acid (FA)-induced purine nucleotide (PN)-inhibited proton conductance. Inhibition of the proton conductance by PN has been considered as a diagnostic of UCP activity. However, conflicting results have been obtained in isolated mitochondria for UCP homologues (i.e., UCP2, UCP3, plant UCP, and protist UCP) where the FFA-activated proton conductance is poorly sensitive to PN under resting respiration conditions. Our recent work clearly indicates that the membranous coenzyme Q, through its redox state, represents a regulator of the inhibition by PN of FFA-activated UCP1 homologues under phosphorylating respiration conditions. Several physiological roles of UCPs have been suggested, including a control of the cellular energy balance as well as the preventive action against oxidative stress. In this paper, we discuss new information emerging from comparative proteomics about the impact of UCPs on mitochondrial physiology, when recombinant UCP1 is expressed in yeast and when UCP2 is over-expressed in hepatic mitochondria during steatosis

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Sluse, Francis ; Université de Liège - ULiège > Département des sciences de la vie > Bioénergétique et physiologie cellulaire

Jarmuszkiewicz, Wieslawa

Navet, Rachel ; Université de Liège - ULiège > GIGA - Formation

Douette, Pierre ; Université de Liège - ULiège > Bioénergétique et physiologie cellulaire

Mathy, Grégory ; Université de Liège - ULiège > Département des sciences de la vie > Bioénergétique et physiologie cellulaire

Sluse-Goffart, Claudine

Language :

English

Title :

Mitochondrial UCPs: New insights into regulation and impact

Publication date :

2006

Event name :

14th European Bioenergetics Conference

Event place :

Moscou, Russia

Event date :

22/27 Juillet 2006

By request :

Yes

Audience :

International

Journal title :

Biochimica et Biophysica Acta. Bioenergetics

ISSN :

0005-2728

eISSN :

1879-2650

Publisher :

Elsevier Science Bv, Amsterdam, Netherlands

Volume :

1757

Issue :

5-6, Suppl 1

Pages :

101

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

FRFC - Fonds de la Recherche Fondamentale Collective

Available on ORBi :

since 04 March 2011

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Scopus citations^®

126

Scopus citations^®
without self-citations

107

OpenCitations

112

OpenAlex citations

137

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