Article (Scientific journals)
Increased plasma malondialdehyde associated with cerebellar structural defects.
RAMAEKERS, Vincent; Bosman, Bernard; Jansen, G. A. et al.
1997In Archives of Disease in Childhood, 77 (3), p. 231-4
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Keywords :
Adolescent; Adult; Cerebellum/abnormalities; Child; Child, Preschool; Epilepsy/blood; Humans; Infant; Lipid Peroxidation; Malondialdehyde/blood; Nervous System Diseases/blood; Pons/abnormalities; Reference Values
Abstract :
[en] BACKGROUND: Malondialdehyde (MDA) in plasma is regarded as an indicator for increased lipid peroxidation. METHOD: Measurements of MDA concentrations in plasma were compared among healthy children (n = 31), patients with neurological disorders or epileptic syndromes (n = 15), and children with pontocerebellar structural defects (n = 31), where the cause or genetic defect remained unknown. RESULTS: In healthy children the median MDA value was 5.86 nmol/ml (mean (SD) value: 6.25 (1.97), range: 3.76-11.19). For the group with various neurological disorders or epilepsy, the values were similar with the median value at 5.66 nmol/ml (range 0.22-10.86). Compared with healthy controls and the neurological/ epileptic group, the 31 children with pontocerebellar structural defects had significantly increased MDA values with a median value at 11.29 nmol/ml (mean (SD) value: 11.62 (3.27), range 3.65-19.22). IMPLICATION: These findings of increased plasma MDA in the majority of children with pontocerebellar structural defects of unknown origin raised the question whether increased lipid peroxidation leads to prenatal and postnatal pontocerebellar maldevelopment or degeneration.
Disciplines :
Neurology
Pediatrics
Author, co-author :
RAMAEKERS, Vincent ;  University Hospital Aachen, Germany > Paediatrics
Bosman, Bernard ;  University Hospital Aachen, Germany > Paediatrics
Jansen, G. A.;  University Hospital Amsterdam, The Netherlands > Paediatrics and Clinical Biochemistry
Wanders, R. J.;  University Hospital Amsterdam, The Netherlands > Paediatrics and Clinical Biochemistry
Language :
English
Title :
Increased plasma malondialdehyde associated with cerebellar structural defects.
Publication date :
September 1997
Journal title :
Archives of Disease in Childhood
ISSN :
0003-9888
eISSN :
1468-2044
Publisher :
BMJ Publishing Group, United Kingdom
Volume :
77
Issue :
3
Pages :
231-4
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 June 2014

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