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Article (Scientific journals)
Haemodynamic effects of intravenous diltiazem at rest and exercise in patients with coronary artery disease.
Legrand, Victor; Hastir, F.; Vandormael, M. et al.
1984In European Heart Journal, 5 (6), p. 456-63
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Keywords :
Adult; Angina Pectoris/drug therapy; Benzazepines/pharmacology; Coronary Disease/drug therapy/physiopathology; Coronary Vessels/drug effects; Diltiazem/adverse effects/pharmacology/therapeutic use; Female; Heart/drug effects; Hemodynamics/drug effects; Humans; Male; Middle Aged; Physical Exertion; Vascular Resistance/drug effects
Abstract :
[en] The acute effects of intravenous diltiazem on exercise performance were studied in 10 patients with coronary artery disease. Haemodynamic measurements were made at rest and during exercise before and after 0.5 mg kg-1 of diltiazem. Diltiazem prolonged the duration of exercise (+2.85 min, P less than 0.001) and delayed the onset of ischaemic ST depression or angina in all patients. The highest tolerated heart rate and pressure rate product were increased in all but one patient after diltiazem. At rest diltiazem decreased mean arterial pressure (-10.8%, P less than 0.005), systemic vascular resistance (SVR) (-11.8%, P less than 0.05) and left ventricular stroke work index (SWI) (-14.1%, P less than 0.005). During exercise under diltiazem therapy, at the level achieved before the drug, the pulmonary capillary wedge pressure (-30%, P less than 0.005) and the SVR (-13.6%, P less than 0.02) were lowered, the SWI (+13%, P less than 0.01) was increased; at the end of exercise only the SVR (-14%, P less than 0.05) was reduced. Two patients experienced angina on lying down and one had orthostatic hypotension after exercise with diltiazem. This study indicates that intravenous diltiazem is a potentially useful agent for the treatment of angina by reducing myocardial oxygen demand at rest and by improving left ventricular performances on exercise.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Legrand, Victor ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie
Hastir, F.
Vandormael, M.
Collignon, P.
Kulbertus, Henri ;  Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Haemodynamic effects of intravenous diltiazem at rest and exercise in patients with coronary artery disease.
Publication date :
1984
Journal title :
European Heart Journal
ISSN :
0195-668X
eISSN :
1522-9645
Publisher :
Oxford University Press, United Kingdom
Volume :
5
Issue :
6
Pages :
456-63
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 June 2014

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