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Article (Scientific journals)
Comparative haemodynamic effects of intravenous flecainide in patients with and without heart failure and with and without beta-blocker therapy.
Legrand, Victor; Materne, P.; Vandormael, M. et al.
1985In European Heart Journal, 6 (8), p. 664-71
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Keywords :
Adult; Aged; Blood Pressure/drug effects; Coronary Disease/drug therapy; Electrocardiography; Female; Flecainide; Heart Rate/drug effects; Hemodynamics/drug effects; Humans; Male; Middle Aged; Myocardial Contraction/drug effects; Myocardial Infarction/drug therapy; Piperidines/blood/pharmacology/therapeutic use; Stroke Volume/drug effects; Vascular Resistance/drug effects
Abstract :
[en] The haemodynamic effects of flecainide were compared in three different subsets of patients with documented coronary disease. Ten patients (A) had no heart failure, 5 patients were on beta blockers (B) and 5 patients had overt heart failure (C). Flecainide was associated with negative inotropic effects that were relatively more pronounced in patients with left ventricular dysfunction: pulmonary wedge pressure increased by 27% in A, by 31% in B and by 42% in C; left ventricular stroke volume and stroke work decreased respectively by 10 and 12% in A, 21 and 19% in B, 26 and 28% in C. Ejection fraction decreased by 9% in A, 13% in B and 20% in C, in relation with an increase in end systolic volume (+9% in A, +10% in B and +5% in C). Absolute changes, however, were not significantly different from one group to another except for the increase of systemic vascular resistance which was more pronounced in C as compared with the other groups. The myocardial depression was also confirmed by the fall in dP/dt that was maximal at the end of injection; dP/dt remained depressed 15 min later despite some improvement. Flecainide thus exerts negative inotropic effects that are maximal at the end of infusion and may be of importance in patients with established left ventricular dysfunction.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Legrand, Victor ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie
Materne, P.
Vandormael, M.
Collignon, P.
Kulbertus, Henri ;  Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Comparative haemodynamic effects of intravenous flecainide in patients with and without heart failure and with and without beta-blocker therapy.
Publication date :
1985
Journal title :
European Heart Journal
ISSN :
0195-668X
eISSN :
1522-9645
Publisher :
Oxford University Press, United Kingdom
Volume :
6
Issue :
8
Pages :
664-71
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 June 2014

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