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Article (Scientific journals)
Characterization of changes in coronary blood flow during the first six seconds after intracoronary contrast injection.
Hodgson, J. M.; Mancini, G. B.; Legrand, Victor et al.
1985In Investigative Radiology, 20 (3), p. 246-52
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Keywords :
Angiography/methods; Animals; Blood Pressure; Coronary Angiography; Coronary Circulation/drug effects; Diatrizoate/analogs & derivatives; Diatrizoate Meglumine/administration & dosage/diagnostic use/pharmacology; Dogs; Electrocardiography; Female; Heart Rate; Injections, Intra-Arterial; Male; Time Factors
Abstract :
[en] With current interest in digital and densitometric angiographic techniques for evaluating coronary blood flow (CBF), the immediate effects of intracoronary contrast injections on CBF are important to establish. We investigated the effects of ECG-gated intracoronary injection of contrast on CBF with different injection rates (1-6 cc/sec), volumes (1/2-6 cc), and contrast concentrations (1/2, full strength). Sixteen open-chest dogs were instrumented with electromagnetic flow probes on the left anterior descending artery. During intracoronary injections of contrast, a characteristic decrease in coronary blood flow to approximately 45% of preinjection levels was seen an average of 1.9 seconds after intracoronary contrast injection. The timing of the depression in coronary flow was most influenced by the rate of contrast injection, and the magnitude of depression in flow was influenced by both the volume and concentration of the contrast injection. Angiographic techniques using the first 6 seconds after injection to obtain CBF measurements should take these characteristic changes into account to avoid possible errors.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Hodgson, J. M.
Mancini, G. B.
Legrand, Victor ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie
Vogel, R. A.
Language :
English
Title :
Characterization of changes in coronary blood flow during the first six seconds after intracoronary contrast injection.
Publication date :
1985
Journal title :
Investigative Radiology
ISSN :
0020-9996
eISSN :
1536-0210
Publisher :
Lippincott Williams & Wilkins, United States - Maryland
Volume :
20
Issue :
3
Pages :
246-52
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 June 2014

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