[en] With current interest in digital and densitometric angiographic techniques for evaluating coronary blood flow (CBF), the immediate effects of intracoronary contrast injections on CBF are important to establish. We investigated the effects of ECG-gated intracoronary injection of contrast on CBF with different injection rates (1-6 cc/sec), volumes (1/2-6 cc), and contrast concentrations (1/2, full strength). Sixteen open-chest dogs were instrumented with electromagnetic flow probes on the left anterior descending artery. During intracoronary injections of contrast, a characteristic decrease in coronary blood flow to approximately 45% of preinjection levels was seen an average of 1.9 seconds after intracoronary contrast injection. The timing of the depression in coronary flow was most influenced by the rate of contrast injection, and the magnitude of depression in flow was influenced by both the volume and concentration of the contrast injection. Angiographic techniques using the first 6 seconds after injection to obtain CBF measurements should take these characteristic changes into account to avoid possible errors.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Hodgson, J. M.
Mancini, G. B.
Legrand, Victor ; Université de Liège - ULiège > Département des sciences cliniques > Cardiologie
Vogel, R. A.
Language :
English
Title :
Characterization of changes in coronary blood flow during the first six seconds after intracoronary contrast injection.
Publication date :
1985
Journal title :
Investigative Radiology
ISSN :
0020-9996
eISSN :
1536-0210
Publisher :
Lippincott Williams & Wilkins, United States - Maryland
Rutishauser W, Bussman W-D, Noseda G, Meier W, Weilauer J. Blood flow measurement through single coronary arteries by roentgen densitometry. Part I. A comparison of flow measured by a radiologic technique applicable in the intact organism and by electromagnetic flowmeter. Am J Roentgenol 1979; 109:12.
Smith HC, Sturm RE, Wood EH. Videodensitometric system for measurement of vessel blood flow, particularly in the coronary arteries, in man. Am J Cardiol 1973;32:144.
Drury JK, Whiting JS, Pfaff JM, Meerbaum S, Corday E, Forrester JS. Validation of myocardial blood flow measurements using digital subtraction angiography (abstr). J Am Coll Cardiol 1984;3: 588.
Vogel R, LeFree M, Bates E, et al. Application of digital techniques to selective coronary arteriography: Use of myocardial contrast appearance time to measure coronary flow reserve. Am Heart J 1984;107:153.
Hodgson JMcB, Aueron FM, Mancini GBJ, et al. A rapid digital angiographic technique for determining relative coronary blood flow: Validation and limitations (abstr). J Am Coll Cardiol 1984;3:588.
Spiller P, Schmiel FK, Politz B, et al. Measurement of systolic and diastolic flow rates in the coronary artery system by x-ray densitometry. Circulation 1983;68:337.
Foerster JM, Link DP, Lantz BMT, Lee G, Holcroft JW, Mason DT. Measurement of coronary reactive hyperemia during clinical angiography by video dilution technique. Acta Radiol Diag 1981;22:209.
Weisz D, Hamby RI, Aintablian A, Voleti C, Fogel R, Wisoff BG. Late coronary bypass graft flow: Quantitative assessment by roentgen-densitometry. Ann Thorac Surg 1979;28:429.
Tragardh B, Lynch P, Tragardh M. Coronary angiography with diatrizoate and metrizamide. Acta Radiol Diag 1976;17:69.
Griggs AM Jr, Nakamura Y, Leunissen RLA, Kasparian H, Novack P. Effects of radiopaque material on phasic coronary flow and myocardial oxygen consumption (abstr). Clin Res 1966; 14:247.
Talbert JL, Joyce EE, Sabiston DC Jr. The effect of intra-arterial injection of radiopaque contrast media on coronary blood flow. Surgery 1959;46:400.
Bassan M, Ganz W, Marcus HS, Swan HJC. The effect of intracoronary injection of contrast medium upon coronary blood flow. Circulation 1975;51:442.
Carson RP, Weber WJ, Wilson WS. Effect of selective coronary arteriography on myocardial blood flow in the intact dog. Am J Med Sci 1969;257:228.
Guzman SV, West JW. Cardiac effects of intracoronary arterial injections of various roentgenographic contrast media. Am Heart J 1959;58:597.
Kloster FE, Friesen WG, Green GS, Judkins MP. Effects of coronary arteriography on myocardial blood flow. Circulation 1972;46:438.
Friesinger GC, Schaffer J, Criley JM, Gaertner RA, Ross RS. Hemodynamic consequences of the injection of radiopaque material. Circulation 1965;31:730.
Lehan PH, Harman MA, Oldewurtel HA. Myocardial water shifts induced by coronary arteriography (abstr). J Clin Invest 1963;42: 950.
Yamazaki H, Aya S, Horikawa M, Matsumura N, Nakamura Y. Effects of radiopaque material on coronary vascular reserve. Jpn Heart J 1975;16:57.
Neter J, Wasserman W. Applied linear statistical models. Homewood: Richard D. Irwin, 1974:477.