Article (Scientific journals)
Rates of CTL Killing in Persistent Viral Infection In Vivo
Elemans, Marjet; Florins, Arnaud; Willems, Luc et al.
2014In PLoS Computational Biology, 4
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Abstract :
[en] The CD8+ cytotoxic T lymphocyte (CTL) response is an important defence against viral invasion. Although CTL-mediated cytotoxicity has been widely studied for many years, the rate at which virus-infected cells are killed in vivo by the CTL response is poorly understood. To date the rate of CTL killing in vivo has been estimated for three virus infections but the estimates differ considerably, and killing of HIV-1-infected cells was unexpectedly low. This raises questions about the typical anti-viral capability of CTL and whether CTL killing is abnormally low in HIV-1. We estimated the rate of killing of infected cells by CD8+ T cells in two distinct persistent virus infections: sheep infected with Bovine Leukemia Virus (BLV) and humans infected with Human T Lymphotropic Virus type 1 (HTLV-1) which together with existing data allows us to study a total of five viruses in parallel. Although both BLV and HTLV-1 infection are characterised by large expansions of chronically activated CTL with immediate effector function ex vivo and no evidence of overt immune suppression, our estimates are at the lower end of the reported range. This enables us to put current estimates into perspective and shows that CTL killing of HIV-infected cells may not be atypically low. The estimates at the higher end of the range are obtained in more manipulated systems and may thus represent the potential rather than the realised CTL efficiency.
Disciplines :
Oncology
Author, co-author :
Elemans, Marjet;  Imperial College London > Section of Immunology
Florins, Arnaud
Willems, Luc  ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Asquith, Becca
Language :
English
Title :
Rates of CTL Killing in Persistent Viral Infection In Vivo
Publication date :
03 April 2014
Journal title :
PLoS Computational Biology
ISSN :
1553-734X
eISSN :
1553-7358
Publisher :
Public Library of Science, San Francisco, United States - California
Volume :
4
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 May 2014

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